Jerzy Krzeszowiak, Ciprian Duta, RadosÅ Aw Pach, Piotr Richter, Zbigniew Lorenc, Andrzej Rutkowski, Wojciech Zegarski, Mariusz Frączek, Łukasz Zyskowski, Maciej Gaciong, Bartosz Skonieczny, Wojciech Polkowski, Vlad Braicu, Michał Święch, Katarzyna Sędłak, Dorian Andrade, Florian Kuhn, Konrad Karcz, Michal Tenderenda, Andrzej Cichocki, Jarosław Kobiela, Piotr Spychalski, Kajetan Ochwat, Aneta Obcowska-Hamerska, Antoni Szczepanik
{"title":"一项国际多中心研究:70岁以上和70岁以上直肠癌患者的分期和治疗比较","authors":"Jerzy Krzeszowiak, Ciprian Duta, RadosÅ Aw Pach, Piotr Richter, Zbigniew Lorenc, Andrzej Rutkowski, Wojciech Zegarski, Mariusz Frączek, Łukasz Zyskowski, Maciej Gaciong, Bartosz Skonieczny, Wojciech Polkowski, Vlad Braicu, Michał Święch, Katarzyna Sędłak, Dorian Andrade, Florian Kuhn, Konrad Karcz, Michal Tenderenda, Andrzej Cichocki, Jarosław Kobiela, Piotr Spychalski, Kajetan Ochwat, Aneta Obcowska-Hamerska, Antoni Szczepanik","doi":"10.21614/chirurgia.3108","DOIUrl":null,"url":null,"abstract":"<p><p><b>Introduction:</b> Colorectal cancer remains one of the major issues in modern healthcare, being one of the most common neoplasms and the second leading cause of cancer-related deaths. Despite significant recent advances, treatment modalities and the popularization of screening programs, treatment course and outcomes still vary among patients. This study aimed to observe the differences in staging, course of treatment, and survival between patients 70 and 70 years old with rectal cancer. Material and <b>Methods:</b> The study was a retrospective analysis of data collected prospectively in nine centers located in Poland, Romania, and Germany. Consecutive patients operated on for rectal cancer between 2013-2019 were included and divided into groups 70 and â?Â¥70. <b>Results:</b> A total of 2443 patients were included with a median age of 66 years and a predominance of male (63.16%). There were no significant differences in terms of sex, tumor localization or staging between the younger and the older group. A significantly higher number of procedures with stoma creation was observed and a lower number of lymph nodes yielded in older patients. There were no significant differences in the rate of R0 resections. The use of preoperative radiotherapy was also higher in the younger group. The rate of complete response did not differ significantly, and the overall survival was significantly lower in older patients. <b>Conclusions:</b> Despite similar staging, older and younger patients receive different treatment course, including less radical surgery and less frequent use of radiotherapy. Overall survival is poorer in older patients in stages I-IV.</p>","PeriodicalId":10171,"journal":{"name":"Chirurgia","volume":"120 2","pages":"131-141"},"PeriodicalIF":0.8000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparison of Staging and Treatment of Rectal Cancer between Patients Younger and Older than 70 years - An International Multicenter Study.\",\"authors\":\"Jerzy Krzeszowiak, Ciprian Duta, RadosÅ Aw Pach, Piotr Richter, Zbigniew Lorenc, Andrzej Rutkowski, Wojciech Zegarski, Mariusz Frączek, Łukasz Zyskowski, Maciej Gaciong, Bartosz Skonieczny, Wojciech Polkowski, Vlad Braicu, Michał Święch, Katarzyna Sędłak, Dorian Andrade, Florian Kuhn, Konrad Karcz, Michal Tenderenda, Andrzej Cichocki, Jarosław Kobiela, Piotr Spychalski, Kajetan Ochwat, Aneta Obcowska-Hamerska, Antoni Szczepanik\",\"doi\":\"10.21614/chirurgia.3108\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Introduction:</b> Colorectal cancer remains one of the major issues in modern healthcare, being one of the most common neoplasms and the second leading cause of cancer-related deaths. Despite significant recent advances, treatment modalities and the popularization of screening programs, treatment course and outcomes still vary among patients. This study aimed to observe the differences in staging, course of treatment, and survival between patients 70 and 70 years old with rectal cancer. Material and <b>Methods:</b> The study was a retrospective analysis of data collected prospectively in nine centers located in Poland, Romania, and Germany. Consecutive patients operated on for rectal cancer between 2013-2019 were included and divided into groups 70 and â?Â¥70. <b>Results:</b> A total of 2443 patients were included with a median age of 66 years and a predominance of male (63.16%). There were no significant differences in terms of sex, tumor localization or staging between the younger and the older group. A significantly higher number of procedures with stoma creation was observed and a lower number of lymph nodes yielded in older patients. There were no significant differences in the rate of R0 resections. The use of preoperative radiotherapy was also higher in the younger group. The rate of complete response did not differ significantly, and the overall survival was significantly lower in older patients. <b>Conclusions:</b> Despite similar staging, older and younger patients receive different treatment course, including less radical surgery and less frequent use of radiotherapy. 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Comparison of Staging and Treatment of Rectal Cancer between Patients Younger and Older than 70 years - An International Multicenter Study.
Introduction: Colorectal cancer remains one of the major issues in modern healthcare, being one of the most common neoplasms and the second leading cause of cancer-related deaths. Despite significant recent advances, treatment modalities and the popularization of screening programs, treatment course and outcomes still vary among patients. This study aimed to observe the differences in staging, course of treatment, and survival between patients 70 and 70 years old with rectal cancer. Material and Methods: The study was a retrospective analysis of data collected prospectively in nine centers located in Poland, Romania, and Germany. Consecutive patients operated on for rectal cancer between 2013-2019 were included and divided into groups 70 and â?¥70. Results: A total of 2443 patients were included with a median age of 66 years and a predominance of male (63.16%). There were no significant differences in terms of sex, tumor localization or staging between the younger and the older group. A significantly higher number of procedures with stoma creation was observed and a lower number of lymph nodes yielded in older patients. There were no significant differences in the rate of R0 resections. The use of preoperative radiotherapy was also higher in the younger group. The rate of complete response did not differ significantly, and the overall survival was significantly lower in older patients. Conclusions: Despite similar staging, older and younger patients receive different treatment course, including less radical surgery and less frequent use of radiotherapy. Overall survival is poorer in older patients in stages I-IV.
期刊介绍:
Chirurgia is a bimonthly journal. In Chirurgia, original papers in the area of general surgery which neither
appeared, nor were sent for publication in other periodicals, can be published. You can send original articles,
new surgical techniques, or comprehensive general reports on surgical topics, clinical case presentations and,
depending on publication space, - reviews of some articles of general interest to surgeons from other publications.
Chirurgia is also a place for sharing information about the activity of various branches of the Romanian Society of
Surgery, information on Congresses and Symposiums organized by the Romanian Society of Surgery and
participation notes in other scientific meetings.
Letters to the editor: Letters commenting on papers published in Chirurgia are welcomed. They should contain
substantive ideas and commentaries supported by appropriate data, and should not exceed 2 pages. Please
submit these letters to the editor through our online system.