一项国际多中心研究:70岁以上和70岁以上直肠癌患者的分期和治疗比较

IF 0.8 Q4 SURGERY
Chirurgia Pub Date : 2025-04-01 DOI:10.21614/chirurgia.3108
Jerzy Krzeszowiak, Ciprian Duta, RadosÅ Aw Pach, Piotr Richter, Zbigniew Lorenc, Andrzej Rutkowski, Wojciech Zegarski, Mariusz Frączek, Łukasz Zyskowski, Maciej Gaciong, Bartosz Skonieczny, Wojciech Polkowski, Vlad Braicu, Michał Święch, Katarzyna Sędłak, Dorian Andrade, Florian Kuhn, Konrad Karcz, Michal Tenderenda, Andrzej Cichocki, Jarosław Kobiela, Piotr Spychalski, Kajetan Ochwat, Aneta Obcowska-Hamerska, Antoni Szczepanik
{"title":"一项国际多中心研究:70岁以上和70岁以上直肠癌患者的分期和治疗比较","authors":"Jerzy Krzeszowiak, Ciprian Duta, RadosÅ Aw Pach, Piotr Richter, Zbigniew Lorenc, Andrzej Rutkowski, Wojciech Zegarski, Mariusz Frączek, Łukasz Zyskowski, Maciej Gaciong, Bartosz Skonieczny, Wojciech Polkowski, Vlad Braicu, Michał Święch, Katarzyna Sędłak, Dorian Andrade, Florian Kuhn, Konrad Karcz, Michal Tenderenda, Andrzej Cichocki, Jarosław Kobiela, Piotr Spychalski, Kajetan Ochwat, Aneta Obcowska-Hamerska, Antoni Szczepanik","doi":"10.21614/chirurgia.3108","DOIUrl":null,"url":null,"abstract":"<p><p><b>Introduction:</b> Colorectal cancer remains one of the major issues in modern healthcare, being one of the most common neoplasms and the second leading cause of cancer-related deaths. Despite significant recent advances, treatment modalities and the popularization of screening programs, treatment course and outcomes still vary among patients. This study aimed to observe the differences in staging, course of treatment, and survival between patients 70 and 70 years old with rectal cancer. Material and <b>Methods:</b> The study was a retrospective analysis of data collected prospectively in nine centers located in Poland, Romania, and Germany. Consecutive patients operated on for rectal cancer between 2013-2019 were included and divided into groups 70 and â?Â¥70. <b>Results:</b> A total of 2443 patients were included with a median age of 66 years and a predominance of male (63.16%). There were no significant differences in terms of sex, tumor localization or staging between the younger and the older group. A significantly higher number of procedures with stoma creation was observed and a lower number of lymph nodes yielded in older patients. There were no significant differences in the rate of R0 resections. The use of preoperative radiotherapy was also higher in the younger group. The rate of complete response did not differ significantly, and the overall survival was significantly lower in older patients. <b>Conclusions:</b> Despite similar staging, older and younger patients receive different treatment course, including less radical surgery and less frequent use of radiotherapy. Overall survival is poorer in older patients in stages I-IV.</p>","PeriodicalId":10171,"journal":{"name":"Chirurgia","volume":"120 2","pages":"131-141"},"PeriodicalIF":0.8000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparison of Staging and Treatment of Rectal Cancer between Patients Younger and Older than 70 years - An International Multicenter Study.\",\"authors\":\"Jerzy Krzeszowiak, Ciprian Duta, RadosÅ Aw Pach, Piotr Richter, Zbigniew Lorenc, Andrzej Rutkowski, Wojciech Zegarski, Mariusz Frączek, Łukasz Zyskowski, Maciej Gaciong, Bartosz Skonieczny, Wojciech Polkowski, Vlad Braicu, Michał Święch, Katarzyna Sędłak, Dorian Andrade, Florian Kuhn, Konrad Karcz, Michal Tenderenda, Andrzej Cichocki, Jarosław Kobiela, Piotr Spychalski, Kajetan Ochwat, Aneta Obcowska-Hamerska, Antoni Szczepanik\",\"doi\":\"10.21614/chirurgia.3108\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Introduction:</b> Colorectal cancer remains one of the major issues in modern healthcare, being one of the most common neoplasms and the second leading cause of cancer-related deaths. Despite significant recent advances, treatment modalities and the popularization of screening programs, treatment course and outcomes still vary among patients. This study aimed to observe the differences in staging, course of treatment, and survival between patients 70 and 70 years old with rectal cancer. Material and <b>Methods:</b> The study was a retrospective analysis of data collected prospectively in nine centers located in Poland, Romania, and Germany. Consecutive patients operated on for rectal cancer between 2013-2019 were included and divided into groups 70 and â?Â¥70. <b>Results:</b> A total of 2443 patients were included with a median age of 66 years and a predominance of male (63.16%). There were no significant differences in terms of sex, tumor localization or staging between the younger and the older group. A significantly higher number of procedures with stoma creation was observed and a lower number of lymph nodes yielded in older patients. There were no significant differences in the rate of R0 resections. The use of preoperative radiotherapy was also higher in the younger group. The rate of complete response did not differ significantly, and the overall survival was significantly lower in older patients. <b>Conclusions:</b> Despite similar staging, older and younger patients receive different treatment course, including less radical surgery and less frequent use of radiotherapy. Overall survival is poorer in older patients in stages I-IV.</p>\",\"PeriodicalId\":10171,\"journal\":{\"name\":\"Chirurgia\",\"volume\":\"120 2\",\"pages\":\"131-141\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chirurgia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21614/chirurgia.3108\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"SURGERY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chirurgia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21614/chirurgia.3108","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 0

摘要

导读:结直肠癌仍然是现代医疗保健中的主要问题之一,是最常见的肿瘤之一,也是癌症相关死亡的第二大原因。尽管最近取得了重大进展,但治疗方式和筛查方案的普及、治疗过程和结果在患者之间仍然存在差异。本研究旨在观察70岁和70岁直肠癌患者在分期、疗程和生存方面的差异。材料和方法:本研究对波兰、罗马尼亚和德国九个中心前瞻性收集的数据进行回顾性分析。纳入2013-2019年连续接受直肠癌手术的患者,分为70组和â?Â¥70组。结果:共纳入2443例患者,中位年龄66岁,男性居多(63.16%)。在性别、肿瘤定位或分期方面,年轻组和老年组没有显著差异。在老年患者中,观察到造口手术的数量明显增加,而淋巴结的数量较少。R0切除率无显著差异。术前放疗的使用在年轻组中也较高。两组患者的完全缓解率无显著差异,老年患者的总生存率明显降低。结论:尽管分期相似,但老年和年轻患者的治疗过程不同,包括较少的根治性手术和较少的放射治疗。老年I-IV期患者的总生存率较低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of Staging and Treatment of Rectal Cancer between Patients Younger and Older than 70 years - An International Multicenter Study.

Introduction: Colorectal cancer remains one of the major issues in modern healthcare, being one of the most common neoplasms and the second leading cause of cancer-related deaths. Despite significant recent advances, treatment modalities and the popularization of screening programs, treatment course and outcomes still vary among patients. This study aimed to observe the differences in staging, course of treatment, and survival between patients 70 and 70 years old with rectal cancer. Material and Methods: The study was a retrospective analysis of data collected prospectively in nine centers located in Poland, Romania, and Germany. Consecutive patients operated on for rectal cancer between 2013-2019 were included and divided into groups 70 and â?¥70. Results: A total of 2443 patients were included with a median age of 66 years and a predominance of male (63.16%). There were no significant differences in terms of sex, tumor localization or staging between the younger and the older group. A significantly higher number of procedures with stoma creation was observed and a lower number of lymph nodes yielded in older patients. There were no significant differences in the rate of R0 resections. The use of preoperative radiotherapy was also higher in the younger group. The rate of complete response did not differ significantly, and the overall survival was significantly lower in older patients. Conclusions: Despite similar staging, older and younger patients receive different treatment course, including less radical surgery and less frequent use of radiotherapy. Overall survival is poorer in older patients in stages I-IV.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Chirurgia
Chirurgia Medicine-Surgery
CiteScore
1.00
自引率
0.00%
发文量
75
审稿时长
4-8 weeks
期刊介绍: Chirurgia is a bimonthly journal. In Chirurgia, original papers in the area of general surgery which neither appeared, nor were sent for publication in other periodicals, can be published. You can send original articles, new surgical techniques, or comprehensive general reports on surgical topics, clinical case presentations and, depending on publication space, - reviews of some articles of general interest to surgeons from other publications. Chirurgia is also a place for sharing information about the activity of various branches of the Romanian Society of Surgery, information on Congresses and Symposiums organized by the Romanian Society of Surgery and participation notes in other scientific meetings. Letters to the editor: Letters commenting on papers published in Chirurgia are welcomed. They should contain substantive ideas and commentaries supported by appropriate data, and should not exceed 2 pages. Please submit these letters to the editor through our online system.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信