{"title":"揭示细胞信号的生物物理学。","authors":"Silvina Ponce Dawson","doi":"10.1007/s12551-025-01308-8","DOIUrl":null,"url":null,"abstract":"<p><p>In this report, I describe some of the subjects and problems that we have addressed over the last 25 years in the area of cell signaling using the tools of biological physics. The report covers part of our work on intracellular Ca <math><mmultiscripts><mrow></mrow> <mrow></mrow> <mrow><mn>2</mn> <mo>+</mo></mrow> </mmultiscripts> </math> signals, pattern formation, transport of messengers in the interior of cells, quantification of biophysical parameters from experiments, and information transmission. The description includes both our modeling and experimental work highlighting how the tools of physics can give useful insights into the workings of biological systems.</p>","PeriodicalId":9094,"journal":{"name":"Biophysical reviews","volume":"17 2","pages":"271-283"},"PeriodicalIF":4.9000,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075082/pdf/","citationCount":"0","resultStr":"{\"title\":\"Biological physics to uncover cell signaling.\",\"authors\":\"Silvina Ponce Dawson\",\"doi\":\"10.1007/s12551-025-01308-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In this report, I describe some of the subjects and problems that we have addressed over the last 25 years in the area of cell signaling using the tools of biological physics. The report covers part of our work on intracellular Ca <math><mmultiscripts><mrow></mrow> <mrow></mrow> <mrow><mn>2</mn> <mo>+</mo></mrow> </mmultiscripts> </math> signals, pattern formation, transport of messengers in the interior of cells, quantification of biophysical parameters from experiments, and information transmission. The description includes both our modeling and experimental work highlighting how the tools of physics can give useful insights into the workings of biological systems.</p>\",\"PeriodicalId\":9094,\"journal\":{\"name\":\"Biophysical reviews\",\"volume\":\"17 2\",\"pages\":\"271-283\"},\"PeriodicalIF\":4.9000,\"publicationDate\":\"2025-04-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075082/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biophysical reviews\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s12551-025-01308-8\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"BIOPHYSICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biophysical reviews","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12551-025-01308-8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"BIOPHYSICS","Score":null,"Total":0}
In this report, I describe some of the subjects and problems that we have addressed over the last 25 years in the area of cell signaling using the tools of biological physics. The report covers part of our work on intracellular Ca signals, pattern formation, transport of messengers in the interior of cells, quantification of biophysical parameters from experiments, and information transmission. The description includes both our modeling and experimental work highlighting how the tools of physics can give useful insights into the workings of biological systems.
期刊介绍:
Biophysical Reviews aims to publish critical and timely reviews from key figures in the field of biophysics. The bulk of the reviews that are currently published are from invited authors, but the journal is also open for non-solicited reviews. Interested authors are encouraged to discuss the possibility of contributing a review with the Editor-in-Chief prior to submission. Through publishing reviews on biophysics, the editors of the journal hope to illustrate the great power and potential of physical techniques in the biological sciences, they aim to stimulate the discussion and promote further research and would like to educate and enthuse basic researcher scientists and students of biophysics. Biophysical Reviews covers the entire field of biophysics, generally defined as the science of describing and defining biological phenomenon using the concepts and the techniques of physics. This includes but is not limited by such areas as: - Bioinformatics - Biophysical methods and instrumentation - Medical biophysics - Biosystems - Cell biophysics and organization - Macromolecules: dynamics, structures and interactions - Single molecule biophysics - Membrane biophysics, channels and transportation