赭曲霉毒素A生物降解的分子研究。

IF 1.8 4区 生物学 Q3 BIOLOGY
Renáta Ábrahám, Erzsébet Baka, Mohammed Al-Nussairawi, András Táncsics, Milán Farkas, István Nagy, Balázs Kriszt, Mátyás Cserháti
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引用次数: 0

摘要

大多数农产品可能暴露于真菌毒素,特别是赭曲霉毒素A (OTA),这可能导致食源性疾病,如肾毒性和全球显著的经济损失。生物解毒是控制OTA污染最有前途的方法。本文综述了OTA的生物降解途径,并讨论了能够降解OTA的微生物及其解毒策略。对食品和饲料解毒的潜在有用酶的详细分析将被报道,强调在科学文献中确定的具体酶的策略。通过对不同OTA水解酶功能的比较分析,发现其降解效率存在显著差异,因此对这些酶进行优化对于开发有效的解毒策略至关重要。本综述强调了利用这些微生物及其酶在污染环境中减轻OTA毒性效应的潜力,并研究了成功应用OTA降解酶技术以促进公共健康和食品安全必须满足的基本要求。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Molecular insights into ochratoxin A biodegradation.

Most of the agricultural products can potentially be exposed to mycotoxins-especially to ochratoxin A (OTA)-, which may cause foodborne diseases such as renal toxicity and notable economic losses worldwide. Biological detoxification is the most promising method to control OTA contamination. To provide a comprehensive understanding, this review summarizes the biodegradation pathways of OTA and discusses microbes capable of degrading OTA and their detoxification strategies. A detailed analysis of potentially useful enzymes for food and feed detoxification will be reported, highlighting specific enzymatic strategies identified in scientific literature. A comparative analysis of the functional capabilities of different OTA hydrolases demonstrates significant variation in degradation efficiency, thus the optimization of these enzymes is essential for the development of effective detoxification strategies. This review underscores the potential of harnessing these microorganisms and their enzymes for mitigating the toxic effects of OTA in contaminated environment and examining the essential requirements that must be met for the successful application of OTA degrading enzyme technology for promoting public health and food safety.

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来源期刊
Biologia futura
Biologia futura Agricultural and Biological Sciences-Agricultural and Biological Sciences (all)
CiteScore
3.50
自引率
0.00%
发文量
27
期刊介绍: How can the scientific knowledge we possess now influence that future? That is, the FUTURE of Earth and life − of humankind. Can we make choices in the present to change our future? How can 21st century biological research ask proper scientific questions and find solid answers? Addressing these questions is the main goal of Biologia Futura (formerly Acta Biologica Hungarica). In keeping with the name, the new mission is to focus on areas of biology where major advances are to be expected, areas of biology with strong inter-disciplinary connection and to provide new avenues for future research in biology. Biologia Futura aims to publish articles from all fields of biology.
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