Chan Ho Kwon, Eva S Safaie, Savannah L Locke, Jannell A Torres, Zhaohui Yang, Xi Chen, Young Dal Jang
{"title":"饲粮中添加25-羟基胆骨化醇对苗猪生长性能、血液维生素D和抗氧化状态的影响。","authors":"Chan Ho Kwon, Eva S Safaie, Savannah L Locke, Jannell A Torres, Zhaohui Yang, Xi Chen, Young Dal Jang","doi":"10.5713/ab.25.0029","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study was conducted to evaluate the effect of dietary 25-hydroxycholecalciferol (25-OHD3) supplementation on growth performance, blood 25-OHD3 level, and antioxidant parameters in nursery pigs.</p><p><strong>Methods: </strong>A total of 48 newly weaned piglets (5.27±1.42 kg initial body weight) were allotted to 3 treatments in 4 replicates with 4 pigs per pen for a 28-d feeding trial in two phases for d 0-14 (Phase 1) and d 14-28 (Phase 2) postweaning with basal diets without supplemental vitamin D3 (VD3). Treatments were: 1) basal diet+2,000 IU/kg VD3 supplementation, 2) basal diet+1,000 IU/kg 25-OHD3 supplementation, and 3) basal diet+2,000 IU/kg 25-OHD3 supplementation. Growth performance, plasma 25-OHD3 and malondialdehyde (MDA) levels, total antioxidant capacity, and superoxide dismutase activity were measured.</p><p><strong>Results: </strong>There was no significant difference in growth performance among dietary treatments until d 21 postweaning. Dietary 25-OHD3 supplementation increased feed intake (p<0.07) and growth rate (p<0.05) greater than the VD3 treatment in d 21-28 and d 14-28 postweaning, resulting in a greater growth rate in the overall period (p = 0.10). Increasing levels of 25-OHD3 supplementation resulted in greater plasma 25-OHD3 concentrations at d 14 and 28 postweaning (p<0.05), while decreasing plasma MDA levels at d 28 postweaning (p<0.05) with no differences in plasma superoxide dismutase activity and total antioxidant capacity. In the broken-line analysis, the estimated plasma 25-OHD3 concentration for plasma MDA concentration to reach the minimum level was 23.7 ng/mL (p<0.05).</p><p><strong>Conclusion: </strong>Supplementing 25-OHD3 in nursery diets increased blood vitamin D status and had potential to enhance feed intake and growth rate in the late nursery period, while reducing oxidative stress compared with VD3 supplementation.</p>","PeriodicalId":7825,"journal":{"name":"Animal Bioscience","volume":" ","pages":"1943-1952"},"PeriodicalIF":2.5000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12415447/pdf/","citationCount":"0","resultStr":"{\"title\":\"Effects of dietary 25-hydroxycholecalciferol supplementation on growth performance, blood vitamin D and antioxidant status in nursery pigs.\",\"authors\":\"Chan Ho Kwon, Eva S Safaie, Savannah L Locke, Jannell A Torres, Zhaohui Yang, Xi Chen, Young Dal Jang\",\"doi\":\"10.5713/ab.25.0029\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study was conducted to evaluate the effect of dietary 25-hydroxycholecalciferol (25-OHD3) supplementation on growth performance, blood 25-OHD3 level, and antioxidant parameters in nursery pigs.</p><p><strong>Methods: </strong>A total of 48 newly weaned piglets (5.27±1.42 kg initial body weight) were allotted to 3 treatments in 4 replicates with 4 pigs per pen for a 28-d feeding trial in two phases for d 0-14 (Phase 1) and d 14-28 (Phase 2) postweaning with basal diets without supplemental vitamin D3 (VD3). Treatments were: 1) basal diet+2,000 IU/kg VD3 supplementation, 2) basal diet+1,000 IU/kg 25-OHD3 supplementation, and 3) basal diet+2,000 IU/kg 25-OHD3 supplementation. Growth performance, plasma 25-OHD3 and malondialdehyde (MDA) levels, total antioxidant capacity, and superoxide dismutase activity were measured.</p><p><strong>Results: </strong>There was no significant difference in growth performance among dietary treatments until d 21 postweaning. Dietary 25-OHD3 supplementation increased feed intake (p<0.07) and growth rate (p<0.05) greater than the VD3 treatment in d 21-28 and d 14-28 postweaning, resulting in a greater growth rate in the overall period (p = 0.10). Increasing levels of 25-OHD3 supplementation resulted in greater plasma 25-OHD3 concentrations at d 14 and 28 postweaning (p<0.05), while decreasing plasma MDA levels at d 28 postweaning (p<0.05) with no differences in plasma superoxide dismutase activity and total antioxidant capacity. In the broken-line analysis, the estimated plasma 25-OHD3 concentration for plasma MDA concentration to reach the minimum level was 23.7 ng/mL (p<0.05).</p><p><strong>Conclusion: </strong>Supplementing 25-OHD3 in nursery diets increased blood vitamin D status and had potential to enhance feed intake and growth rate in the late nursery period, while reducing oxidative stress compared with VD3 supplementation.</p>\",\"PeriodicalId\":7825,\"journal\":{\"name\":\"Animal Bioscience\",\"volume\":\" \",\"pages\":\"1943-1952\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12415447/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Animal Bioscience\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.5713/ab.25.0029\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/5/12 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"AGRICULTURE, DAIRY & ANIMAL SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Animal Bioscience","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.5713/ab.25.0029","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/12 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"AGRICULTURE, DAIRY & ANIMAL SCIENCE","Score":null,"Total":0}
Effects of dietary 25-hydroxycholecalciferol supplementation on growth performance, blood vitamin D and antioxidant status in nursery pigs.
Objective: This study was conducted to evaluate the effect of dietary 25-hydroxycholecalciferol (25-OHD3) supplementation on growth performance, blood 25-OHD3 level, and antioxidant parameters in nursery pigs.
Methods: A total of 48 newly weaned piglets (5.27±1.42 kg initial body weight) were allotted to 3 treatments in 4 replicates with 4 pigs per pen for a 28-d feeding trial in two phases for d 0-14 (Phase 1) and d 14-28 (Phase 2) postweaning with basal diets without supplemental vitamin D3 (VD3). Treatments were: 1) basal diet+2,000 IU/kg VD3 supplementation, 2) basal diet+1,000 IU/kg 25-OHD3 supplementation, and 3) basal diet+2,000 IU/kg 25-OHD3 supplementation. Growth performance, plasma 25-OHD3 and malondialdehyde (MDA) levels, total antioxidant capacity, and superoxide dismutase activity were measured.
Results: There was no significant difference in growth performance among dietary treatments until d 21 postweaning. Dietary 25-OHD3 supplementation increased feed intake (p<0.07) and growth rate (p<0.05) greater than the VD3 treatment in d 21-28 and d 14-28 postweaning, resulting in a greater growth rate in the overall period (p = 0.10). Increasing levels of 25-OHD3 supplementation resulted in greater plasma 25-OHD3 concentrations at d 14 and 28 postweaning (p<0.05), while decreasing plasma MDA levels at d 28 postweaning (p<0.05) with no differences in plasma superoxide dismutase activity and total antioxidant capacity. In the broken-line analysis, the estimated plasma 25-OHD3 concentration for plasma MDA concentration to reach the minimum level was 23.7 ng/mL (p<0.05).
Conclusion: Supplementing 25-OHD3 in nursery diets increased blood vitamin D status and had potential to enhance feed intake and growth rate in the late nursery period, while reducing oxidative stress compared with VD3 supplementation.