Photoinduced Ene-Reductase Catalysis via EDA Complexes.

Flavin-dependent ene-reductases (EREDs) have emerged as powerful biocatalysts for the asymmetric reduction of various substrates. This review focuses on the recent advances in light-induced electron transfer-mediated reduction via EDA (electron donor-acceptor) complexes catalyzed by EREDs. Upon photoexcitation, the flavin cofactor transitions to an excited state, significantly enhancing its reduction potential. We discuss the mechanistic insights into how light activation alters the redox properties of EREDs, leading to more efficient catalysis. The review also highlights the broadened application scope of photoexcited EREDs in organic synthesis. Additionally, we explore the challenges and future directions in optimizing these light-driven biocatalytic processes. This overview provides a foundation for the development of novel, light-controlled enzymatic systems with enhanced catalytic performance.