Synthetic Glycopolymers in Tumor Immunotherapy.

Glycopolymers, as an emerging immunomodulatory material, exhibit considerable promise in the field of tumor immunotherapy. Compared to native saccharides, they offer significant advantages, including enhanced immune activity, controllable structure and sequence, elevated stability, and high purity. By mimicking the multivalency of native sugar chains, glycopolymers significantly enhance their interactions with receptors, a phenomenon known as the "glycocluster effect." Glycopolymers are capable of modulating immune cell functions, inhibiting tumor immune evasion, and reconfiguring the tumor microenvironment. This review provides a comprehensive overview of recent advancements in the application of glycopolymers, protein-glycopolymer conjugates, glycopolymer-based micro/nanoparticles, and glycopolymer-engineered cells in tumor immunotherapy. These glycopolymer-based materials enhance antitumor immune responses by specifically interacting with immune cell surface receptors, significantly improving the precision and efficacy of immunotherapy, and providing valuable insights for the development of innovative therapeutic strategies in cancer treatment.