一种用于过氧化氢和H2O2蒸气选择性检测的萘酰亚胺衍生物荧光探针。

IF 2.7 3区化学 Q2 CHEMISTRY, ANALYTICAL

Analytical Methods Pub Date : 2025-05-16 DOI:10.1039/d5ay00179j

Lin-E Guo, Yuqiang Zhao, Jiazhong Zhang, Ying Zhou

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引用次数: 0

摘要

三过氧化三丙酮（TATP）是恐怖分子最常用的简易爆炸装置之一。过氧化氢（H2O2）是过氧化氢基TATP的合成前驱体和降解产物。本文合成并表征了一种“开启”型H2O2选择性萘酰亚胺衍生物荧光探针，对H2O2的检测具有较高的选择性和灵敏度。该探针通过供体激发光诱导电子转移（d-PET）机制工作，在H2O2的作用下产生60倍的荧光增强。结果表明，该探针对H2O2的检测范围为0 ~ 40 μM，检测限为59.6 nM。值得注意的是，该探针成功地用于浓度低于10 ppb的H2O2蒸汽的高灵敏度快速检测，产生肉眼可见的结果。它也被成功地用于细胞成像。

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A naphthalimide derivative-based fluorescent probe for selective detection of hydrogen peroxide and H₂O₂ vapor.

Triacetone triperoxide (TATP) is one of the most commonly used improvised explosive devices by terrorists. Hydrogen peroxide (H₂O₂) serves as a synthetic precursor and degradation product of peroxide-based TATP. Herein, a "turn-on" pattern H₂O₂-selective naphthalimide derivative fluorescent probe was synthesized and characterized, demonstrating high selectivity and sensitivity for the detection of H₂O₂. The probe operates via a donor-excited photo-induced electron transfer (d-PET) mechanism, resulting in a 60-fold fluorescence enhancement in response to H₂O₂. As a result, the proposed probe can detect H₂O₂ within a linear range of 0 to 40 μM, with a detection limit of 59.6 nM. Notably, the probe was successfully employed for the rapid detection of H₂O₂ vapor with high sensitivity at concentrations below 10 ppb, yielding visible results to the naked eye. It has also been successfully used for cell imaging.