珊瑚虫和珊瑚幼虫的胞外细胞类型具有共同的特征,并将牛磺酸与沉降调节联系起来

IF 11.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Julia Ramon-Mateu, Anna Ferraioli, Núria Teixidó, Isabelle Domart-Coulon, Evelyn Houliston, Richard R. Copley
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引用次数: 0

摘要

生态学家和进化生物学家都对幼虫定居感兴趣,他们提出,用于基质选择的前感觉系统为动物大脑提供了基础。然而,包括刺胞动物(珊瑚、水母、海葵和水螅类动物)在内的沉降的细胞和分子调控尚不清楚。我们生成并比较了三种刺胞动物物种:半水母(Clytia hemisphaerica)和珊瑚Astroides calycularis和Pocillopora acuta的浮藻幼虫的前(aboral)转录组和单细胞RNA测序数据集。通过整合这些数据集并描述流产细胞类型,我们定义了planula流产端常见的细胞特征,并确定了细胞类型的分支特异性特化。在共同的特征中,涉及牛磺酸摄取和分解代谢的基因在不同的专门的流产细胞类型中表达。在功能分析中,使用牛磺酸和牛磺酸抑制沉降。这些发现确定了扁平膜的分子和细胞结构,并暗示了局部牛磺酸破坏在调节沉降中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Aboral cell types of Clytia and coral larvae have shared features and link taurine to the regulation of settlement
Larval settlement is of interest both for ecologists and for evolutionary biologists, who have proposed that anterior sensory systems for substrate selection provided the basis for animal brains. Nevertheless, the cellular and molecular regulation of settlement, including in Cnidaria (corals, jellyfish, sea anemones, and hydroids), is not well understood. We generated and compared anterior (aboral) transcriptomes and single-cell RNA sequencing datasets from the planula larvae of three cnidarian species: the jellyfish Clytia hemisphaerica and the corals Astroides calycularis and Pocillopora acuta. Integrating these datasets and characterizing aboral cell types, we defined common cellular features of the planula aboral end and identified clade-specific specializations in cell types. Among shared features were genes implicated in taurine uptake and catabolism expressed in distinct specialized aboral cell types. In functional assays using both Clytia and Astroides planulae, exogenous taurine inhibited settlement. These findings define the molecular and cellular architecture of the planula aboral pole and implicate localized taurine destruction in regulating settlement.
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来源期刊
Science Advances
Science Advances 综合性期刊-综合性期刊
CiteScore
21.40
自引率
1.50%
发文量
1937
审稿时长
29 weeks
期刊介绍: Science Advances, an open-access journal by AAAS, publishes impactful research in diverse scientific areas. It aims for fair, fast, and expert peer review, providing freely accessible research to readers. Led by distinguished scientists, the journal supports AAAS's mission by extending Science magazine's capacity to identify and promote significant advances. Evolving digital publishing technologies play a crucial role in advancing AAAS's global mission for science communication and benefitting humankind.
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