1-烷氧基-6-芳基-2-氰基-4-[（3-氰基-4,5,6,7-四氢苯并[b]-噻吩-2-基）氨基]-1,6-二氧己-2,4-二烯-3-油酸钾的合成及抗伤活性

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2025-05-15 DOI:10.1007/s11172-025-4608-4

D. V. Lipin, V. M. Shadrin, S. K. Metlyakova, P. S. Silaichev, R. R. Makhmudov, D. A. Shipilovskikh

引用次数: 0

摘要

氧呋喃在2-[（2-氧呋喃-3(2H)-乙基）氨基]-4,5,6,7-四氢苯并[b]噻吩-3-碳腈中开环，与烷基氰乙酸酯和ButOK反应得到新的1-烷氧基-6-芳基-2-氰基-4-[（3-氰-4,5,6,7-四氢苯并[b]噻吩-2-基）氨基]-1,6-二氧己-2,4-二烯-3-酸盐。合成的化合物具有明显的抗伤活性和低毒性（毒性为几乎无毒物质的IV级）。

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Synthesis and antinociceptive activity of potassium 1-alkoxy-6-aryl-2-cyano-4-[(3-cyano-4,5,6,7-tetrahydrobenzo[b]-thiophen-2-yl)amino]-1,6-dioxohexa-2,4-dien-3-olates

The oxofuran ring opening in 2-[(2-oxofuran-3(2H)-ylidene)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitriles upon the reaction with alkyl cyanoacetates and Bu^tOK gave new potassium 1-alkoxy-6-aryl-2-cyano-4-[(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)amino]-1,6-dioxohexa-2,4-dien-3-olates. The synthesized compounds demonstrated pronounced antinociceptive activity and low toxicity (the toxicity class IV of practically nontoxic substances).

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.