n -烷基-2-芳基肼基-4-氧丁烷酰胺的合成及抗炎活性研究

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2025-05-15 DOI:10.1007/s11172-025-4606-6

E. I. Denisova, O. V. Zvereva, D. V. Lipin, S. V. Chashchina, I. N. Chernov, E. S. Denislamova, D. A. Shipilovskikh, N. M. Igidov

引用次数: 0

摘要

4-取代N ' -（5-芳基-2-氧呋喃-3(2H)-酰基）-苯并肼与不同的烷基胺反应，得到新的改性N-烷基-2-芳基酰肼-4-氧丁酰胺。合成的化合物在体内表现出明显的抗炎活性，证明了它们是治疗炎症的有希望的候选药物。

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Synthesis and study of anti-inflammatory activity of N-alkyl-2-aroylhydrazinylidene-4-oxobutanamides

The oxofuran ring opening of 4-substituted N′-(5-aryl-2-oxofuran-3(2H)-ylidene)-benzhydrazides upon the reaction with different alkylamines gave new modified N-alkyl-2-aroylhydrazinylidene-4-oxobutanamides. The synthesized compounds demonstrated pronounced anti-inflammatory activity in vivo and proved themselves as promising drug candidates for the treatment of inflammation.

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.