含P(O)CH2NH-和P(O) ch2nsi胺的合成和功能化

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2025-05-15 DOI:10.1007/s11172-025-4599-1

Yu. N. Bubnov, A. A. Prishchenko, M. V. Livantsov, O. P. Novikova, L. I. Livantsova, S. V. Baranin

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引用次数: 0

摘要

以N，N '，N″-三取代六氢-1,3,5-三嗪与三价磷酸酯为原料，制备了含P(O) ch2nhh和P(O)CH2NSi基团的磷取代胺。合成子的NH和NSi单元的各种功能化反应（2-羧乙基化，2-吡啶乙基化和酰化）在温和的条件下进行，并以高收率得到新的功能化含磷胺。由此产生的化合物是有前途的生物活性物质，水溶性多齿配体和有效的萃取剂。

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Synthesis and functionalization of P(O)CH2NH- and P(O)CH2NSi-containing amines

Convenient syntheses of phosphorus-substituted amines containing P(O)CH₂NH and P(O)CH₂NSi moieties based on the reaction between N,N′,N″-trisubstituted hexahydro-1,3,5-triazines and trivalent phosphorus acid esters have been developed. Various functionalization reactions (2-carboxyethylation, 2-pyridylethylation, and acylation) of the NH and NSi units of the resulting synthons proceed under mild conditions and give new functionalized phosphorus-containing amines in high yields. The resulting compounds are of interest as promising biologically active substances, water-soluble polydentate ligands, and effective extractants.

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.