区域特异性合成n9 -烷基化8-氮杂嘌呤的方法

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2025-05-15 DOI:10.1007/s11172-025-4596-4

K. V. Savateev, D. A. Gazizov, P. A. Slepukhin, V. L. Rusinov

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引用次数: 0

摘要

在重构方法的基础上，提出了n9 -烷基化8-氮杂嘌呤的区域特异性合成方法。结果表明，在重氮化反应条件下，2,5-二氨基-4-烷基氨基嘧啶可以高产地转化为相应的2-氨基- n - 9-烷基-8-氮杂嘌呤。证明了合成天然核苷类似物的可能性，即在假核苷部分含有羟基的8-氮杂嘌呤，包括抗病毒药物Penciclovir类似物的合成。

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Regiospecific method for the synthesis of N9-alkylated 8-azapurines

Regiospecific method for the synthesis of N⁹-alkylated 8-azapurines was proposed based on the reconstructive methodology. It was shown that 2,5-diamino-4-alkylaminopyrimidines under the diazotization reaction conditions were converted into the corresponding 2-amino-N⁹-alkyl-8-azapurines in high yields. A possibility for the synthesis of analogs of natural nucleosides, 8-azapurines containing hydroxy groups in the pseudoriboside moiety, was demonstrated, including the synthesis of analog of antiviral drug Penciclovir.

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.