基于丹酚的抗生素多模态识别AIE材料

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-05-01 DOI:10.1002/ajoc.202500207

Shagun , Abhimanew Dhir

{"title":"基于丹酚的抗生素多模态识别AIE材料","authors":"Shagun , Abhimanew Dhir","doi":"10.1002/ajoc.202500207","DOIUrl":null,"url":null,"abstract":"<div><div>A dansyl‐isoniazid conjugate (DISH) is designed and synthesized which exhibits Aggregation‐Induced Emission (AIE) in MeOH : H<sub>2</sub>O (20 : 80). This AIE Material is utilized for detection of different antibiotics having carboxylic acid, amide and thioamide functionalities. The material shows a multimodal recognition behaviour having maximum affinity with a fluorescence intensification (236 %) (φ=0.68) on addition of 2.0 μM levofloxacin (LEV) whereas the quenching of fluorescence emission is observed on addition of prothionamide (PTH) (8.0 μM). To test the practical application of the DISH, we performed smartphone‐based detection wherein RGB colour picker app is used to study the colour variation of probe in urine samples spiked with same concentration of LEV (2.0 μM) and PTH (8.0 μM).</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 5","pages":"Article e202500207"},"PeriodicalIF":2.8000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dansyl Based AIE Material for Multimodal Recognition of Antibiotics\",\"authors\":\"Shagun , Abhimanew Dhir\",\"doi\":\"10.1002/ajoc.202500207\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>A dansyl‐isoniazid conjugate (DISH) is designed and synthesized which exhibits Aggregation‐Induced Emission (AIE) in MeOH : H<sub>2</sub>O (20 : 80). This AIE Material is utilized for detection of different antibiotics having carboxylic acid, amide and thioamide functionalities. The material shows a multimodal recognition behaviour having maximum affinity with a fluorescence intensification (236 %) (φ=0.68) on addition of 2.0 μM levofloxacin (LEV) whereas the quenching of fluorescence emission is observed on addition of prothionamide (PTH) (8.0 μM). To test the practical application of the DISH, we performed smartphone‐based detection wherein RGB colour picker app is used to study the colour variation of probe in urine samples spiked with same concentration of LEV (2.0 μM) and PTH (8.0 μM).</div></div>\",\"PeriodicalId\":130,\"journal\":{\"name\":\"Asian Journal of Organic Chemistry\",\"volume\":\"14 5\",\"pages\":\"Article e202500207\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Asian Journal of Organic Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S219358072500100X\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S219358072500100X","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}

引用次数: 0

摘要

设计并合成了一种在MeOH: H2O（20:8 0）中具有聚集诱导发射（AIE）特性的丹酰异烟肼偶联物（DISH）。该AIE材料用于检测具有羧酸、酰胺和硫酰胺功能的不同抗生素。当左氧氟沙星（LEV）浓度为2.0 μM时，材料的荧光增强幅度为236% (φ=0.68)，而当丙硫酰胺（PTH）浓度为8.0 μM时，材料的荧光猝灭。为了测试DISH的实际应用，我们进行了基于智能手机的检测，其中使用RGB选色器应用程序研究了相同浓度LEV （2.0 μM）和PTH （8.0 μM）的尿液样品中探针的颜色变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Dansyl Based AIE Material for Multimodal Recognition of Antibiotics

A dansyl‐isoniazid conjugate (DISH) is designed and synthesized which exhibits Aggregation‐Induced Emission (AIE) in MeOH : H₂O (20 : 80). This AIE Material is utilized for detection of different antibiotics having carboxylic acid, amide and thioamide functionalities. The material shows a multimodal recognition behaviour having maximum affinity with a fluorescence intensification (236 %) (φ=0.68) on addition of 2.0 μM levofloxacin (LEV) whereas the quenching of fluorescence emission is observed on addition of prothionamide (PTH) (8.0 μM). To test the practical application of the DISH, we performed smartphone‐based detection wherein RGB colour picker app is used to study the colour variation of probe in urine samples spiked with same concentration of LEV (2.0 μM) and PTH (8.0 μM).

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.