铜催化苯甲酸的氧化酯化和酰胺化反应

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-05-01 DOI:10.1002/ajoc.202500137

Daisy Gogoi , Sauvik Kashyap , Hrishikesh Talukdar , Prodeep Phukan

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引用次数: 0

摘要

利用铜- DMAP络合物进行C−O和C−N键形成交叉偶联反应，开发了一种新的高效方法。该催化剂以过氧化二叔丁基（DTBP）为氧化剂，使用苯甲酸、苯酰胺和磺胺，实现了苯基C - H键的原子经济酯化、酰胺化和磺化。该配合物具有空气稳定性，易于制备，催化剂负载低，可以在露天条件下无碱和无配体合成各种苯酯、N -苄基苯酰胺和N -苄基芳基磺胺，反应时间短，产率高。

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Copper‐Catalyzed Oxidative Esterification and Amidation of Benzylic Hydrocarbons

A new and efficient methodology has been developed using a Copper‐DMAP complex to perform C−O and C−N bond‐forming cross‐coupling reactions. The catalyst enables atom‐economic esterification, amidation, and sulfamidation of benzylic C−H bonds using benzoic acids, benzamides, and sulfonamides employing di‐tert‐butyl peroxide (DTBP) as the oxidant. The air‐stable and easy‐to‐prepare complex with low catalyst loading enables the base‐ and ligand‐free synthesis of a variety of benzyl esters, N‐benzyl benzamides, and N‐benzyl aryl sulfonamides in open‐air conditions with good to excellent yields within a short reaction time.

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.