级联Michael/分子内转酰胺反应合成含三氟甲基吡唑烷- 3 -酮衍生物

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-05-01 DOI:10.1002/ajoc.202500145

Ryo Tsuyusaki , Dr. Kosuke Nakashima , Yasuyuki Matsushima , Dr. Shin‐ichi Hirashima , Prof. Dr. Tsuyoshi Miura

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引用次数: 0

摘要

3 -苯酰基- 2 -吲哚酮衍生物以三氟甲基为新型Michael受体，与肼进行级联Michael/分子内转酰胺反应，得到相应的吡唑烷- 3 -酮衍生物，收率高，具有优异的非对映选择性。这些含有三氟甲基的吡唑烷- 3 - 1衍生物可以进一步转化为各种有价值的杂环化合物。

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Synthesis of Pyrazolidin‐3‐one Derivatives Bearing Trifluoromethyl Group via Cascade Michael/Intramolecular Transamidation Reactions

The cascade Michael/intramolecular transamidation reactions of 3‐phenacylidene‐2‐indolinone derivatives bearing a trifluoromethyl group as a novel Michael acceptor with hydrazines yielded the corresponding pyrazolidin‐3‐one derivatives in good to high yields with excellent diastereoselectivity. These pyrazolidin‐3‐one derivatives, bearing trifluoromethyl groups, can be further transformed into various valuable heterocyclic compounds.

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.