铜催化分子内氧化C - H键胺化合成苯并呋喃[3,2 - b]吲哚骨架

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-05-01 DOI:10.1002/ajoc.202400702

Peramalla Edukondalu , Nidhi Ravi , Raghavender Matta , Gugulothu Kishan , Dr. K. Shiva Kumar

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引用次数: 0

摘要

我们描述了一种铜催化的有氧氧化分子内C−H胺化反应，可以构建广泛应用于药物化学的苯并呋喃[3,2‐b]吲哚。已经发现，所开发的胺化反应可以有效地合成各种苯并呋喃[3,2‐b]吲哚，否则很难用其他方法制造。该方法也适用于吲哚类和噻吩类。此外，本方法为制备苯并呋喃[3,2‐b]吲哚提供了经济和实用的优点。

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Copper‐Catalyzed Synthesis of Benzofuro[3,2‐b]Indole Frame Work via Intramolecular Oxidative C−H Bond Amination

We described a Copper‐catalyzed aerobic oxidative intramolecular C−H amination that enables the construction of benzofuro[3,2‐b]indole that are widely applicable in medicinal chemistry. It has been found that the developed amination is efficient in synthesizing a variety of benzofuro[3,2‐b]indoles that are otherwise difficult to make by other methods. This methodology is also extended to indoles and thiophenes. Additionally the present method offers both economic and practical advantages for making benzofuro[3,2‐b]indole.

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.