Chiron实验丙型肝炎病毒疫苗的抗原性和EM特性

IF 4.5 3区医学 Q2 IMMUNOLOGY

Vaccine Pub Date : 2025-05-16 DOI:10.1016/j.vaccine.2025.127239

Shr-Hau Hung , Jonathan L. Torres , Fang Chen , Erick Giang , Andrew B. Ward , Mansun Law

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引用次数: 0

摘要

Chiron实验性丙型肝炎疫苗是迄今为止唯一一种基于包膜的丙型肝炎疫苗候选疫苗，在1期试验中具有免疫原性和安全性，尽管其有效性尚未得到检验。本研究通过免疫测定和电镜检查了疫苗抗原的抗原特性，揭示了AR1/5表位的不一致表现。该疫苗在人类和非人类灵长类动物中主要引起株特异性中和抗体，这突出了合理抗原设计以提高疫苗广度的必要性。

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Antigenic and EM characterization of the Chiron experimental hepatitis C virus vaccine

The Chiron experimental HCV vaccine, the only envelope-based HCV vaccine candidate to date, was immunogenic and safe in a phase 1 trial, though its efficacy remains untested. This study examined the antigenic properties of the vaccine antigens by immunoassays and EM, revealing inconsistent presentation of AR1/5 epitopes. The vaccine elicited mainly strain-specific neutralizing antibodies in humans and non-human primates, highlighting the need for rational antigen design to improve vaccine breadth.

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来源期刊

Vaccine 医学-免疫学

CiteScore

8.70

自引率

5.50%

发文量

992

审稿时长

131 days

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