Fatty acid desaturases in non-photosynthetic bacteria: classification, regulation, and roles in plasma membrane function and cellular homeostasis

Fatty acid desaturases are key enzymes that catalyze the desaturation of acyl lipid chains by regioselectively introducing double bonds into saturated or pre-existing alkene fatty acids to produce unsaturated fatty acids. While extensive studies have focused on desaturases in higher organisms, research on these enzymes in non-photosynthetic bacteria remains limited, largely due to insufficient structural and functional data. This review aims to summarize the current knowledge on the structural features and catalytic mechanisms of desaturases in non-photosynthetic bacteria, shedding light on the sophisticated regulatory strategies underlying unsaturated fatty acid biosynthesis. In addition, factors influencing desaturase activity are presented and analyzed. This comprehensive review provides insights into bacterial homeostatic adaptation to environmental changes and highlights potential applications in nutraceutical development and therapeutic target identification.