成纤维细胞活化蛋白-α是头颈部鳞状细胞癌中与铁下垂相关的潜在预后生物标志物

IF 2.3 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry and Biophysics Reports Pub Date : 2025-05-15 DOI:10.1016/j.bbrep.2025.102046

Kun Cui , Shifu Tang , Jing Wei , Wanping Wang , Yaoming Deng

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引用次数: 0

摘要

头颈部鳞状细胞癌（HNSC）是全球第六大常见癌症，每年约有70万新病例。由于其异质性，可靠的生物标志物对指导治疗至关重要。成纤维细胞激活蛋白（FAP）与HNSC的进展有关，但其在铁下垂和ceRNA网络中的具体参与尚不清楚。在这项研究中，研究人员分析了来自癌症基因组图谱（TCGA） HNSC数据集的数据，以研究FAP表达与药物敏感性、临床特征、甲基化状态、铁死亡、免疫浸润、预后和ceRNA网络之间的关系。结果显示，FAP在HNSC组织中的表达明显高于正常组织，并与25种抗肿瘤药物敏感性增加、预后较差和不利的临床病理特征有关。较低的FAP甲基化水平也与较高的mRNA表达和较差的预后相关。鉴定出13个铁下垂相关基因（FRGs），并鉴定出4个不同的铁下垂簇，其中一个簇（C3）表现出较高的存活率。FAP进一步与多种免疫细胞类型、免疫标记物以及PI3K-Akt和TGF-β等关键通路相关。此外，我们还建立了一个与HNSC患者总生存率相关的ceRNA网络（NOP14-AS1/hsa-miRNA-30e-5p/FAP）。这些发现表明，FAP可能作为HNSC中有希望的预后生物标志物，影响铁下垂和肿瘤微环境，为未来的治疗提供潜在的靶点。

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Fibroblast activation protein-α is a potential prognostic biomarker related to ferroptosis in head and neck squamous cell carcinoma

Head and neck squamous cell carcinoma (HNSC) is the sixth most prevalent cancer worldwide, with approximately 700,000 new cases each year. Due to its heterogeneity, reliable biomarkers are crucial for guiding treatment. Fibroblast activation protein (FAP) has been implicated in HNSC progression, but its specific involvement in ferroptosis and the ceRNA network is still not well understood.

In this study, data from The Cancer Genome Atlas (TCGA) HNSC dataset were analyzed to examine the relationship between FAP expression and drug sensitivity, clinical features, methylation status, ferroptosis, immune infiltration, prognosis, and ceRNA networks. The results showed that FAP expression was significantly higher in HNSC tissues compared to normal tissues and was linked to increased sensitivity to 25 antitumor drugs, as well as poorer prognosis and unfavorable clinicopathological features. Lower methylation levels of FAP were also associated with higher mRNA expression and worse outcomes.

Thirteen ferroptosis-related genes (FRGs) were identified, and four distinct ferroptosis clusters were characterized, with one cluster (C3) showing better survival rates. FAP was further linked to multiple immune cell types, immune markers, and key pathways such as PI3K-Akt and TGF-β. Additionally, a ceRNA network (NOP14-AS1/hsa-miRNA-30e-5p/FAP) was established, which correlated with overall survival in HNSC patients. These findings suggest that FAP may serve as a promising prognostic biomarker in HNSC, influencing both ferroptosis and the tumor microenvironment, providing potential targets for future therapies.

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来源期刊

Biochemistry and Biophysics Reports Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

4.60

自引率

0.00%

发文量

191

审稿时长

59 days

期刊介绍： Open access, online only, peer-reviewed international journal in the Life Sciences, established in 2014 Biochemistry and Biophysics Reports (BB Reports) publishes original research in all aspects of Biochemistry, Biophysics and related areas like Molecular and Cell Biology. BB Reports welcomes solid though more preliminary, descriptive and small scale results if they have the potential to stimulate and/or contribute to future research, leading to new insights or hypothesis. Primary criteria for acceptance is that the work is original, scientifically and technically sound and provides valuable knowledge to life sciences research. We strongly believe all results deserve to be published and documented for the advancement of science. BB Reports specifically appreciates receiving reports on: Negative results, Replication studies, Reanalysis of previous datasets.