介孔polydopamine@CeO2纳米颗粒用于光声引导光热治疗抑制关节炎

IF 4.6 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience Pub Date : 2025-05-03 DOI:10.1016/j.isci.2025.112576

Huazhen Liu , Jingjing Wang , Chenyang Zhao , Rui Zhang , Ming Wang , Yuxin Jiang , Desheng Sun , Yanglong Hou , Meng Yang

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引用次数: 0

摘要

类风湿关节炎（RA）的特点是氧气供应不足和活性氧（ROS）的过量产生，从而加剧了滑膜炎症。我们将介孔聚多巴胺（MPDA）纳米粒子与CeO2结合合成MPDA@CeO2纳米粒子（NPs），用于光声成像（PAI）引导的协同光控PTT/促氧/ ros消除疗法。在近红外（NIR）激光照射下，MPDA@CeO2 NPs触发光热转化以根除炎症细胞并释放CeO2， CeO2具有消除ROS和释放氧气的催化活性。热量同时增加了氧气释放和ros消耗效率，进一步对抗炎症的有害环境。我们在体外和体内验证了MPDA@CeO2的治疗效果。我们进一步应用多波长PAI观察NPs在体内的分布和处理过程中氧饱和度的变化。本研究强调MPDA@CeO2通过影像引导协同治疗抑制RA关节炎的治疗价值。

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Mesoporous polydopamine@CeO2 nanoparticles for photoacoustic-guided photothermal therapy in suppressing arthritis

Rheumatoid arthritis (RA) is characterized by poor oxygen supply and overproduction of reactive oxygen species (ROS), thereby exacerbating synovial inflammation. We synthesized MPDA@CeO₂ nanoparticles (NPs) by incorporating mesoporous polydopamine (MPDA) NPs and CeO₂ for photoacoustic imaging (PAI)-guided synergistic light-controlled PTT/oxygen-boosting/ROS-eliminating therapy. Upon irradiation with a near-infrared (NIR) laser, MPDA@CeO₂ NPs trigger photothermal conversion to eradicate inflammatory cells and release CeO₂, which have a catalytic activity to eliminate ROS and release oxygen. The oxygen-release and ROS-depleting efficiency was simultaneously augmented by heat to further combat the harmful environment of inflammation. We validated the therapeutic effect of MPDA@CeO₂ in vitro and in vivo. We further applied multiwavelength PAI to observe the distribution of NPs and the change in oxygen saturation during the treatment process in vivo. The study highlights the therapeutic value of MPDA@CeO₂ in inhibiting arthritis in RA through imaging-guided synergistic therapy.

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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