增塑剂暴露与生殖功能障碍：评估双酚A和邻苯二甲酸酯对pcos相关不孕妇女卵巢储备的影响

IF 3.3 4区医学 Q2 REPRODUCTIVE BIOLOGY

Reproductive toxicology Pub Date : 2025-05-14 DOI:10.1016/j.reprotox.2025.108949

Jalpa Patel , Hiral Chaudhary , Sonal Panchal , Rushikesh Joshi

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引用次数: 0

摘要

多囊卵巢综合征（PCOS）是育龄妇女中一种常见的内分泌疾病，常导致不孕。本研究探讨内分泌干扰物（EDCs）对pcos相关性不孕女性卵巢储备参数的影响。从古吉拉特邦艾哈迈达巴德Nagori博士不育研究所招募了61名多囊卵巢综合征妇女，年龄29.90 ± 3.64岁。采用高效液相色谱法测定血清双酚A （BPA）、邻苯二甲酸一乙基己基酯（MEHP）和邻苯二甲酸二乙基己基酯（DEHP）水平。评估卵巢储备标志物，包括窦卵泡计数（AFC）和抗勒氏激素（AMH）水平。还分析了激素谱和代谢参数。使用Pearson相关分析和回归分析评估EDCs与卵巢储备标志物之间的相关性。研究发现血清平均水平BPA(77.80 ±51.82  ng / ml), MEHP(37.43 ±19.85  μg / ml),以及DEHP(5.77 ±7.21  μg / ml)。参与者表现出典型的多囊卵巢综合征激素特征，睾酮和AMH水平升高，并观察到明显的胰岛素抵抗。相关分析显示AMH水平与AFC呈正相关（r = 0.47,p = 0.01）。然而，没有发现EDC暴露与卵巢储备标志物之间的显著关联。在参与者中注意到子宫腺肌症和双侧多囊卵巢的高患病率。虽然代谢和激素紊乱在多囊卵巢综合征中很突出，但EDCs对卵巢储备参数的直接影响似乎很小。本研究强调了在管理多囊卵巢综合征相关不孕症中解决代谢健康和环境暴露的必要性，以改善生殖结果。

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Plasticizer exposure and reproductive dysfunction: Assessing bisphenol A and phthalate esters impact on ovarian reserve in women with PCOS-associated infertility

Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder among women of reproductive age, frequently causing infertility. This study investigates the influence of endocrine-disrupting chemicals (EDCs) on ovarian reserve parameters in women with PCOS-related infertility. A cohort of 61 women with PCOS, aged 29.90 ± 3.64 years, was recruited from Dr. Nagori’s Institute for Infertility in Ahmedabad, Gujarat. Serum levels of Bisphenol A (BPA), Mono-ethylhexyl phthalate (MEHP), and Di-ethylhexyl phthalate (DEHP) were measured using high-performance liquid chromatography (HPLC). Ovarian reserve markers were assessed, including antral follicle count (AFC) and anti-Müllerian hormone (AMH) levels. Hormonal profiles and metabolic parameters were also analyzed. Correlations between EDCs and ovarian reserve markers were evaluated using Pearson correlation and regression analyses. The study found serum mean levels of BPA (77.80 ± 51.82 ng/ml), MEHP (37.43 ± 19.85 μg/ml), and DEHP (5.77 ± 7.21 μg/ml). Participants exhibited typical PCOS hormonal profiles with elevated testosterone and AMH levels, and significant insulin resistance was observed. Correlation analysis showed a positive relationship between AMH levels and AFC (r = 0.47, p = 0.01). However, no significant associations were found between EDC exposure and ovarian reserve markers. A high prevalence of adenomyosis and bilateral polycystic ovaries was noted among the participants. While metabolic and hormonal disruptions are prominent in PCOS, the direct impact of EDCs on ovarian reserve parameters appears minimal. This study highlights the necessity of addressing metabolic health and environmental exposures in managing PCOS related infertility to improve reproductive outcomes.

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来源期刊

Reproductive toxicology 生物-毒理学

CiteScore

6.50

自引率

3.00%

发文量

131

审稿时长

45 days

期刊介绍： Drawing from a large number of disciplines, Reproductive Toxicology publishes timely, original research on the influence of chemical and physical agents on reproduction. Written by and for obstetricians, pediatricians, embryologists, teratologists, geneticists, toxicologists, andrologists, and others interested in detecting potential reproductive hazards, the journal is a forum for communication among researchers and practitioners. Articles focus on the application of in vitro, animal and clinical research to the practice of clinical medicine. All aspects of reproduction are within the scope of Reproductive Toxicology, including the formation and maturation of male and female gametes, sexual function, the events surrounding the fusion of gametes and the development of the fertilized ovum, nourishment and transport of the conceptus within the genital tract, implantation, embryogenesis, intrauterine growth, placentation and placental function, parturition, lactation and neonatal survival. Adverse reproductive effects in males will be considered as significant as adverse effects occurring in females. To provide a balanced presentation of approaches, equal emphasis will be given to clinical and animal or in vitro work. Typical end points that will be studied by contributors include infertility, sexual dysfunction, spontaneous abortion, malformations, abnormal histogenesis, stillbirth, intrauterine growth retardation, prematurity, behavioral abnormalities, and perinatal mortality.