{"title":"黄酮类化合物作为生物增强剂：对其改善药物传递和治疗结果的潜力的重要综述","authors":"Rakesh Mishra , Jitendra Hiwarkar , Abhishek Nikam , Tanaji Nandgude , Vivekanand Chatap , Abhishek Jha","doi":"10.1016/j.prenap.2025.100251","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><div>The purpose of this review is to explore how flavonoids can enhance the bioavailability and effectiveness of various medicinal substances as bioenhancers. The focus is on examining the interactions of flavonoids with medications, enzymes, and biological barriers to improve therapeutic outcomes. The main aim is to demonstrate the potential benefits of incorporating flavonoids as additives in pharmaceutical formulations to enhance drug delivery and improve health outcomes.</div></div><div><h3>Methods</h3><div>Comprehensive literature search was undertaken, covering research from early developments to current findings, using online search tools (PubMed, Google Scholar, Science Direct and Scopus).</div></div><div><h3>Results</h3><div>The review findings suggest that flavonoids have significant potential as bioenhancers, playing a crucial role in increasing the bioavailability and efficacy of different medicinal compounds. Through synergistic interactions with medications and biological systems, flavonoids contribute to improving treatment outcomes. Additionally, the review also pointed the pathways that underlie flavonoid-mediated bio-enhancement, and synergistic actions illuminating their potential use in pharmaceutical formulations for enhanced clinical efficacy and optimised drug delivery.</div></div><div><h3>Conclusion</h3><div>This review underscores the significant role of flavonoids as bioenhancers, highlighting their ability to synergistically improve the bioavailability and efficacy of pharmaceutical compounds. By elucidating the underlying mechanisms of flavonoid-drug interactions, this study provides valuable insights for leveraging flavonoids in drug delivery strategies mainly in the area of cancer and antibiotic therapy<em><strong>.</strong></em></div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100251"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Flavonoids as bioenhancers: A critical review on their potential to improve drug delivery and therapeutic outcomes\",\"authors\":\"Rakesh Mishra , Jitendra Hiwarkar , Abhishek Nikam , Tanaji Nandgude , Vivekanand Chatap , Abhishek Jha\",\"doi\":\"10.1016/j.prenap.2025.100251\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><div>The purpose of this review is to explore how flavonoids can enhance the bioavailability and effectiveness of various medicinal substances as bioenhancers. The focus is on examining the interactions of flavonoids with medications, enzymes, and biological barriers to improve therapeutic outcomes. The main aim is to demonstrate the potential benefits of incorporating flavonoids as additives in pharmaceutical formulations to enhance drug delivery and improve health outcomes.</div></div><div><h3>Methods</h3><div>Comprehensive literature search was undertaken, covering research from early developments to current findings, using online search tools (PubMed, Google Scholar, Science Direct and Scopus).</div></div><div><h3>Results</h3><div>The review findings suggest that flavonoids have significant potential as bioenhancers, playing a crucial role in increasing the bioavailability and efficacy of different medicinal compounds. Through synergistic interactions with medications and biological systems, flavonoids contribute to improving treatment outcomes. Additionally, the review also pointed the pathways that underlie flavonoid-mediated bio-enhancement, and synergistic actions illuminating their potential use in pharmaceutical formulations for enhanced clinical efficacy and optimised drug delivery.</div></div><div><h3>Conclusion</h3><div>This review underscores the significant role of flavonoids as bioenhancers, highlighting their ability to synergistically improve the bioavailability and efficacy of pharmaceutical compounds. By elucidating the underlying mechanisms of flavonoid-drug interactions, this study provides valuable insights for leveraging flavonoids in drug delivery strategies mainly in the area of cancer and antibiotic therapy<em><strong>.</strong></em></div></div>\",\"PeriodicalId\":101014,\"journal\":{\"name\":\"Pharmacological Research - Natural Products\",\"volume\":\"7 \",\"pages\":\"Article 100251\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-05-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacological Research - Natural Products\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2950199725001119\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacological Research - Natural Products","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2950199725001119","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Flavonoids as bioenhancers: A critical review on their potential to improve drug delivery and therapeutic outcomes
Purpose
The purpose of this review is to explore how flavonoids can enhance the bioavailability and effectiveness of various medicinal substances as bioenhancers. The focus is on examining the interactions of flavonoids with medications, enzymes, and biological barriers to improve therapeutic outcomes. The main aim is to demonstrate the potential benefits of incorporating flavonoids as additives in pharmaceutical formulations to enhance drug delivery and improve health outcomes.
Methods
Comprehensive literature search was undertaken, covering research from early developments to current findings, using online search tools (PubMed, Google Scholar, Science Direct and Scopus).
Results
The review findings suggest that flavonoids have significant potential as bioenhancers, playing a crucial role in increasing the bioavailability and efficacy of different medicinal compounds. Through synergistic interactions with medications and biological systems, flavonoids contribute to improving treatment outcomes. Additionally, the review also pointed the pathways that underlie flavonoid-mediated bio-enhancement, and synergistic actions illuminating their potential use in pharmaceutical formulations for enhanced clinical efficacy and optimised drug delivery.
Conclusion
This review underscores the significant role of flavonoids as bioenhancers, highlighting their ability to synergistically improve the bioavailability and efficacy of pharmaceutical compounds. By elucidating the underlying mechanisms of flavonoid-drug interactions, this study provides valuable insights for leveraging flavonoids in drug delivery strategies mainly in the area of cancer and antibiotic therapy.
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