使用参数化建模的人工智能驱动的脊柱植入物设计优化

IF 5.4 2区 医学 Q1 BIOPHYSICS
Idowu O. Malachi , Adebukola O. Olawumi , B.I. Oladapo
{"title":"使用参数化建模的人工智能驱动的脊柱植入物设计优化","authors":"Idowu O. Malachi ,&nbsp;Adebukola O. Olawumi ,&nbsp;B.I. Oladapo","doi":"10.1016/j.colsurfb.2025.114753","DOIUrl":null,"url":null,"abstract":"<div><div>This study aimed to enhance vertebral implant design by using a parametric spine model and advanced simulation techniques to evaluate biomechanical behaviours under dynamic physiological conditions using Finite Element Analysis (FEA) in ANSYS Workbench. The primary objective was to refine implant designs to improve surgical outcomes and patient safety. We incorporated the anisotropic material properties of Magnesium-Rare Earth-Zirconium (Mg-RE-Zr) alloys, focusing on their Young's modulus (40–50 GPa), Poisson's ratio (0.35), and yield strengths (0.193 GPa tensile, 0.255 GPa compressive) to simulate real-world stress and deformation scenarios. Using Finite Element Analysis (FEA), we conducted a series of simulations to examine stress distribution and deformation patterns across various implant models under static and dynamic loads. These simulations provided detailed insights, revealing that maximum equivalent stresses could reach up to 0.160 GPa, with deformations ranging from 0.01875 mm at a lower modulus to 0.015 mm at a higher modulus, showcasing the influence of material stiffness on implant performance. The model demonstrated high accuracy, with an error margin of less than 5 % when validated against analysis test data. This research makes a significant contribution to the field by providing a validated method for predicting and enhancing the biomechanical performance of spinal implants, thereby ensuring their reliability and efficacy in clinical applications.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"253 ","pages":"Article 114753"},"PeriodicalIF":5.4000,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"AI-driven optimization of spinal implant design using parametric modelling\",\"authors\":\"Idowu O. Malachi ,&nbsp;Adebukola O. Olawumi ,&nbsp;B.I. Oladapo\",\"doi\":\"10.1016/j.colsurfb.2025.114753\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>This study aimed to enhance vertebral implant design by using a parametric spine model and advanced simulation techniques to evaluate biomechanical behaviours under dynamic physiological conditions using Finite Element Analysis (FEA) in ANSYS Workbench. The primary objective was to refine implant designs to improve surgical outcomes and patient safety. We incorporated the anisotropic material properties of Magnesium-Rare Earth-Zirconium (Mg-RE-Zr) alloys, focusing on their Young's modulus (40–50 GPa), Poisson's ratio (0.35), and yield strengths (0.193 GPa tensile, 0.255 GPa compressive) to simulate real-world stress and deformation scenarios. Using Finite Element Analysis (FEA), we conducted a series of simulations to examine stress distribution and deformation patterns across various implant models under static and dynamic loads. These simulations provided detailed insights, revealing that maximum equivalent stresses could reach up to 0.160 GPa, with deformations ranging from 0.01875 mm at a lower modulus to 0.015 mm at a higher modulus, showcasing the influence of material stiffness on implant performance. The model demonstrated high accuracy, with an error margin of less than 5 % when validated against analysis test data. This research makes a significant contribution to the field by providing a validated method for predicting and enhancing the biomechanical performance of spinal implants, thereby ensuring their reliability and efficacy in clinical applications.</div></div>\",\"PeriodicalId\":279,\"journal\":{\"name\":\"Colloids and Surfaces B: Biointerfaces\",\"volume\":\"253 \",\"pages\":\"Article 114753\"},\"PeriodicalIF\":5.4000,\"publicationDate\":\"2025-05-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Colloids and Surfaces B: Biointerfaces\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0927776525002607\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOPHYSICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Colloids and Surfaces B: Biointerfaces","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0927776525002607","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOPHYSICS","Score":null,"Total":0}
引用次数: 0

摘要

本研究旨在通过参数化脊柱模型和先进的仿真技术,在ANSYS Workbench中使用有限元分析(FEA)来评估动态生理条件下的生物力学行为,从而增强椎体植入物的设计。主要目的是改进种植体设计,以改善手术效果和患者安全。我们结合了镁-稀土-锆(Mg-RE-Zr)合金的各向异性材料特性,重点研究了它们的杨氏模量(40-50 GPa)、泊松比(0.35)和屈服强度(0.193 GPa拉伸、0.255 GPa压缩)来模拟真实世界的应力和变形场景。利用有限元分析(FEA),我们进行了一系列的模拟,以检查各种种植体模型在静态和动态载荷下的应力分布和变形模式。这些模拟提供了详细的见解,揭示了最大等效应力可以达到0.160 GPa,变形范围从低模量的0.01875 mm到高模量的0.015 mm,显示了材料刚度对植入物性能的影响。该模型具有较高的准确性,与分析测试数据进行验证时,误差范围小于5 %。本研究为预测和提高脊柱植入物的生物力学性能提供了一种有效的方法,从而确保了其在临床应用中的可靠性和有效性,对该领域做出了重大贡献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
AI-driven optimization of spinal implant design using parametric modelling
This study aimed to enhance vertebral implant design by using a parametric spine model and advanced simulation techniques to evaluate biomechanical behaviours under dynamic physiological conditions using Finite Element Analysis (FEA) in ANSYS Workbench. The primary objective was to refine implant designs to improve surgical outcomes and patient safety. We incorporated the anisotropic material properties of Magnesium-Rare Earth-Zirconium (Mg-RE-Zr) alloys, focusing on their Young's modulus (40–50 GPa), Poisson's ratio (0.35), and yield strengths (0.193 GPa tensile, 0.255 GPa compressive) to simulate real-world stress and deformation scenarios. Using Finite Element Analysis (FEA), we conducted a series of simulations to examine stress distribution and deformation patterns across various implant models under static and dynamic loads. These simulations provided detailed insights, revealing that maximum equivalent stresses could reach up to 0.160 GPa, with deformations ranging from 0.01875 mm at a lower modulus to 0.015 mm at a higher modulus, showcasing the influence of material stiffness on implant performance. The model demonstrated high accuracy, with an error margin of less than 5 % when validated against analysis test data. This research makes a significant contribution to the field by providing a validated method for predicting and enhancing the biomechanical performance of spinal implants, thereby ensuring their reliability and efficacy in clinical applications.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Colloids and Surfaces B: Biointerfaces
Colloids and Surfaces B: Biointerfaces 生物-材料科学:生物材料
CiteScore
11.10
自引率
3.40%
发文量
730
审稿时长
42 days
期刊介绍: Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信