钌催化手性δ-羟基-β-酮酸衍生物的不对称加氢反应

IF 3.3 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-05-17 DOI:10.1021/acs.joc.4c02766

Limin Xu, Yuxuan Zhang, Yan Lu, Zhaoguo Zhang

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引用次数: 0

摘要

钌催化多功能化酮的立体选择性不对称加氢一直是一个巨大的挑战，相关的成功研究很少报道。本文报道了钌催化手性δ-羟基-β-酮酸衍生物的不对称加氢反应，该反应具有优异的非对构选择性（高达99%）。该方法为合成纯的合成-和-3,5-二羟基酸衍生物提供了新的途径，这些衍生物是天然产物和药物分子的关键中间体，如他汀类药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Ru-Catalyzed Asymmetric Hydrogenation of Chiral δ-Hydroxy-β-Keto Acid Derivatives

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Ru-Catalyzed Asymmetric Hydrogenation of Chiral δ-Hydroxy-β-Keto Acid Derivatives

Ru-catalyzed stereoselective asymmetric hydrogenation of multifunctionalized ketones has been a formidable challenge, and few related successful works have been reported. Herein, we report our research on Ru-catalyzed asymmetric hydrogenation of chiral δ-hydroxy-β-keto acid derivatives, which achieves excellent diastereoselectivity (up to >99% de). This procedure provides a new route for the synthesis of pure syn- and anti-3,5-dihydroxy acid derivatives, which serve as key intermediates in natural products and drug molecules, such as statins.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.