1,3 -偶极环加成法合成吡咯烷酮- 3 -酮和螺吡咯烷酮

IF 2.7 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2025-05-16 DOI:10.1002/ejoc.202500390

Rayhane Hammami, Lucas Mele, Soufiane Touil, David Virieux, Jean-François Poisson, Tahar Ayad, Benjamin Darses

引用次数: 0

摘要

报道了一种通用的、有效的微波辅助（3+2）环加成反应在硝基酮和烯基烯之间合成氟-磷吡咯烷酮- 3 -酮和螺吡咯烷酮- 3 -酮膦酸盐。在所有转化过程中，产物都以中等到良好的产量分离出来，并且完全为4,5‐反式非对映异构体

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of Pyrrolidin-3-Ones and Spiropyrrolidinones by 1,3-Dipolar Cycloadditions of Nitrones with Allenylphosphonates

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Synthesis of Pyrrolidin-3-Ones and Spiropyrrolidinones by 1,3-Dipolar Cycloadditions of Nitrones with Allenylphosphonates

A general and effective (3 + 2) cycloaddition reaction between nitrones and allenes to synthesize fluoro-phosphonopyrrolidin-3-ones, as well as spiropyrrolidin-3-one phosphonates is reported under microwave heating. The products have been isolated in moderate to good yields and exclusively as 4,5-trans diastereoisomers in all transformations.

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.