抗vegf注射和新生血管性年龄相关性黄斑变性缓解期患者黄斑萎缩进展

IF 3.7 2区 医学 Q1 OPHTHALMOLOGY
Nehal Nailesh Mehta, Ines Doris Nagel, Akshay Agnihotri, Fritz Gerald Paguiligan Kalaw, Anna Heinke, Lingyun Cheng, Dirk-Uwe Bartsch, William R Freeman
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引用次数: 0

摘要

目的探讨持续注射抗血管内皮生长因子(VEGF)对新生血管性年龄相关性黄斑变性(nAMD)缓解期黄斑萎缩(MA)进展的影响。方法回顾性队列研究,对59只至少缓解6个月(疾病不活动)的nAMD眼睛进行分析,并将其分为两组。1组患者缓解(假期)后停止抗vegf注射。在组2中,尽管不活动(维持),仍继续注射。采用海德堡光谱仪(Heidelberg Spectralis)的蓝色自身荧光图像,测量初始注射、缓解开始和最新可用缓解点时的MA面积。在连续光谱域光学相干断层扫描中,没有视网膜下出血、视网膜内液、视网膜下液或与液体相关的视网膜下高反射物质被用来确认疾病的不活动(缓解)。测量两组患者缓解期MA的进展率。结果第1组30只眼平均接受16.97次注射,39.2个月,停药21个月。2组29只眼平均接受27.1次注射,持续时间为62.16个月;其余29只眼平均接受11.59次注射,持续时间为19.32个月。在缓解期,维持组的MA进展快于休假组(p=0.03)。结论缓解期的nAMD维持注射可显著增加MA的进展。如有合理要求,可提供资料。如向水资源基金提出合理要求,可提供数据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Anti-VEGF injections and macular atrophy progression in patients with neovascular age-related macular degeneration in remission
Aims To determine the effect of continuing anti-vascular endothelial growth factor (VEGF) injections on the progression of macular atrophy (MA) during remission of neovascular age-related macular degeneration (nAMD). Methods In this retrospective cohort study, 59 eyes with nAMD with at least 6-month remission (disease inactivity) were analysed and were grouped into two. In group 1, anti-VEGF injections were stopped after remission (holiday). In group 2, injections were continued despite inactivity (maintenance). Using blue autofluorescence images via Heidelberg Spectralis, MA area was measured at initial injection, remission onset and the latest available remission point. The absence of subretinal haemorrhage, intraretinal fluid, subretinal fluid or subretinal hyper-reflective material associated with fluid on serial spectral domain optical coherence tomography scans was used to confirm the inactivity of the disease (remission). The rate of progression of MA during the period of remission was measured for the two groups. Results In group 1, 30 eyes received a mean of 16.97 injections over 39.2 months, followed by 21 months of drug holiday. In group 2, 29 eyes received a mean of 27.1 injections over 62.16 months, followed by a mean of 11.59 injections over 19.32 months for maintenance. The MA in the maintenance group progressed faster than the holiday group during remission (p=0.03). Conclusions Maintenance injections for nAMD in remission significantly increase progression of MA. Data are available on reasonable request. Data are available on reasonable request to WRF.
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来源期刊
CiteScore
10.30
自引率
2.40%
发文量
213
审稿时长
3-6 weeks
期刊介绍: The British Journal of Ophthalmology (BJO) is an international peer-reviewed journal for ophthalmologists and visual science specialists. BJO publishes clinical investigations, clinical observations, and clinically relevant laboratory investigations related to ophthalmology. It also provides major reviews and also publishes manuscripts covering regional issues in a global context.
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