Erika M. Vitale, Amina H. Tbaba, Kaitlyn Tam, Kyle R. Gossman, Adam S. Smith
{"title":"异性配对改变雄性草原田鼠脑岛社会性诱导的GCaMP和多巴胺活性","authors":"Erika M. Vitale, Amina H. Tbaba, Kaitlyn Tam, Kyle R. Gossman, Adam S. Smith","doi":"10.1111/nyas.15363","DOIUrl":null,"url":null,"abstract":"The prairie vole (<jats:italic>Microtus ochrogaster</jats:italic>) is a monogamous rodent species which displays selective social behaviors to conspecifics after establishing a pair‐bonded relationship, specifically partner‐directed affiliation and stranger‐directed aggression. This social selectivity relies on the ability of an individual to respond appropriately to a social context and requires salience detection and valence assignment. The anterior insular cortex (aIC) has been implicated in stimulus processing and categorization across a variety of contexts, but its regulation of pair bond–induced social selectivity in prairie voles has not been studied. Here, we examined whether neural activity and gene expression in the aIC change during male–female pairings in male prairie voles. Opposite‐sex pairing was characterized by changes to calcium and dopamine transients in the aIC that corresponded with the display of social selectivity across pair bond maturation. Furthermore, D1 and D2 receptor mRNA expression was significantly higher in males after 48 h of cohabitation with a female partner compared to same‐sex housed males, and D2 mRNA remained elevated after a week of cohabitation. Together, these results implicate a role for dopamine and its receptors in the aIC across the transition from early‐ to late‐phase pair bonding.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"23 1","pages":""},"PeriodicalIF":4.1000,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Opposite‐sex pairing alters social‐induced GCaMP and dopamine activity in the insula of male prairie voles\",\"authors\":\"Erika M. Vitale, Amina H. Tbaba, Kaitlyn Tam, Kyle R. Gossman, Adam S. Smith\",\"doi\":\"10.1111/nyas.15363\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The prairie vole (<jats:italic>Microtus ochrogaster</jats:italic>) is a monogamous rodent species which displays selective social behaviors to conspecifics after establishing a pair‐bonded relationship, specifically partner‐directed affiliation and stranger‐directed aggression. This social selectivity relies on the ability of an individual to respond appropriately to a social context and requires salience detection and valence assignment. The anterior insular cortex (aIC) has been implicated in stimulus processing and categorization across a variety of contexts, but its regulation of pair bond–induced social selectivity in prairie voles has not been studied. Here, we examined whether neural activity and gene expression in the aIC change during male–female pairings in male prairie voles. Opposite‐sex pairing was characterized by changes to calcium and dopamine transients in the aIC that corresponded with the display of social selectivity across pair bond maturation. Furthermore, D1 and D2 receptor mRNA expression was significantly higher in males after 48 h of cohabitation with a female partner compared to same‐sex housed males, and D2 mRNA remained elevated after a week of cohabitation. Together, these results implicate a role for dopamine and its receptors in the aIC across the transition from early‐ to late‐phase pair bonding.\",\"PeriodicalId\":8250,\"journal\":{\"name\":\"Annals of the New York Academy of Sciences\",\"volume\":\"23 1\",\"pages\":\"\"},\"PeriodicalIF\":4.1000,\"publicationDate\":\"2025-05-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of the New York Academy of Sciences\",\"FirstCategoryId\":\"103\",\"ListUrlMain\":\"https://doi.org/10.1111/nyas.15363\",\"RegionNum\":3,\"RegionCategory\":\"综合性期刊\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of the New York Academy of Sciences","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1111/nyas.15363","RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
Opposite‐sex pairing alters social‐induced GCaMP and dopamine activity in the insula of male prairie voles
The prairie vole (Microtus ochrogaster) is a monogamous rodent species which displays selective social behaviors to conspecifics after establishing a pair‐bonded relationship, specifically partner‐directed affiliation and stranger‐directed aggression. This social selectivity relies on the ability of an individual to respond appropriately to a social context and requires salience detection and valence assignment. The anterior insular cortex (aIC) has been implicated in stimulus processing and categorization across a variety of contexts, but its regulation of pair bond–induced social selectivity in prairie voles has not been studied. Here, we examined whether neural activity and gene expression in the aIC change during male–female pairings in male prairie voles. Opposite‐sex pairing was characterized by changes to calcium and dopamine transients in the aIC that corresponded with the display of social selectivity across pair bond maturation. Furthermore, D1 and D2 receptor mRNA expression was significantly higher in males after 48 h of cohabitation with a female partner compared to same‐sex housed males, and D2 mRNA remained elevated after a week of cohabitation. Together, these results implicate a role for dopamine and its receptors in the aIC across the transition from early‐ to late‐phase pair bonding.
期刊介绍:
Published on behalf of the New York Academy of Sciences, Annals of the New York Academy of Sciences provides multidisciplinary perspectives on research of current scientific interest with far-reaching implications for the wider scientific community and society at large. Each special issue assembles the best thinking of key contributors to a field of investigation at a time when emerging developments offer the promise of new insight. Individually themed, Annals special issues stimulate new ways to think about science by providing a neutral forum for discourse—within and across many institutions and fields.