通过原位聚合稳定金纳米四足体用于优越的光声和光热应用。

IF 9.6 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Letters Pub Date : 2025-05-16 DOI:10.1021/acs.nanolett.5c01764

Jing Wang,Huazhen Chen,Dazhi Chen,Yuchao Luo,Zhi-Li Shen,Ning-Ning Zhang,Biqin Dong,Wenjing Tian,Kun Liu,Bin Xu

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引用次数: 0

摘要

金纳米四足体（NTPs）具有尖锐的分支尖端，高表面体积比和近红外（NIR）区域强局部表面等离子体共振，使其成为生物医学应用的候选材料。然而，它们的实际应用受到结构不稳定性和在复杂生理环境中生物相容性不足的限制。在这项研究中，我们开发了一种创新的原位自由基聚合技术，将ntp包裹在一个薄的交联两性离子聚合物外壳中，形成高度稳定和生物相容性的纳米颗粒（NTP@XP）。聚合物外壳保留了四足结构，并通过不同单体的聚合使ntp具有可调的表面性质。在近红外辐照下，NTP@XP表现出增强的光声成像和体外光热转换性能。在小鼠体内，NTP@XP的防污和生物相容性涂层允许持久成像并抑制肿瘤再生。这项工作建立了原位聚合作为稳定NTPs的强大策略，为各种生物医学领域铺平了道路。

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Stabilizing Gold Nanotetrapods via in Situ Polymerization for Superior Photoacoustic and Photothermal Applications.

Gold nanotetrapods (NTPs) possess sharp branched tips, high surface-to-volume ratios, and strong localized surface plasmon resonance in the near-infrared (NIR) region, making them candidates for biomedical applications. However, their practical use is limited by structural instability and inadequate biocompatibility in complex physiological environments. In this study, we developed an innovative in situ radical polymerization technique to encapsulate NTPs with a thin, cross-linked zwitterionic polymer shell, forming highly stable and biocompatible nanoparticles (NTP@XP). The polymer shell preserved the tetrapod structure and endowed NTPs with tunable surface properties through the polymerization of different monomers. Under NIR irradiation, NTP@XP exhibited enhanced photoacoustic imaging and a photothermal conversion performance in vitro. In vivo, the antifouling and biocompatible coating of NTP@XP allowed durable imaging and suppressed tumor regrowth in mice. This work establishes in situ polymerization as a robust strategy to stabilize NTPs, paving the way for various biomedical fields.

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来源期刊

Nano Letters 工程技术-材料科学：综合

CiteScore

16.80

自引率

2.80%

发文量

1182

审稿时长

1.4 months

期刊介绍： Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including: - Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale - Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies - Modeling and simulation of synthetic, assembly, and interaction processes - Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance - Applications of nanoscale materials in living and environmental systems Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.