Akihiro Takamiya, Thomas Vande Casteele, Filip Bouckaert, Margot Ga Van Cauwenberge, Maarten Laroy, François-Laurent De Winter, Patrick Dupont, Jan Van den Stock, Michel Koole, Koen Van Laere, Louise Emsell, Mathieu Vandenbulcke
{"title":"老年抑郁症患者白质加速老化：来自18f氟替他莫PET成像的证据","authors":"Akihiro Takamiya, Thomas Vande Casteele, Filip Bouckaert, Margot Ga Van Cauwenberge, Maarten Laroy, François-Laurent De Winter, Patrick Dupont, Jan Van den Stock, Michel Koole, Koen Van Laere, Louise Emsell, Mathieu Vandenbulcke","doi":"10.1016/j.bpsc.2025.03.013","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Late-life depression (LLD) is associated with white matter (WM) alterations. Current evidence indicates amyloid PET tracers as sensitive and reliable markers for evaluating normal-appearing WM (NAWM) on magnetic resonance imaging (MRI), showing an association between lower uptake and Alzheimer's disease pathology and higher uptake with age-related changes. Utilizing this novel and reliable technique, we aimed to distinguish two hypothetical models for neurobiology of LLD: the pathological neurodegenerative model and the accelerated aging model.</p><p><strong>Methods: </strong>In this monocentric cross-sectional study, a total of 103 participants, including 61 patients with LLD (age 73.8±7.0 years, 41 female) and 42 healthy controls (age 72.5±7.6 years, 28 female), underwent PET imaging with <sup>18</sup>F-flutemetamol, MRI, and clinical assessment. T2-weighted fluid-attenuated inversion recovery (FLAIR) images were segmented into WM hyperintensities (WMH) and NAWM.</p><p><strong>Results: </strong><sup>18</sup>F-flutemetamol standardized uptake value ratio (SUVR) in WMH was significantly lower than that in NAWM (t=7.8, df=102, p<0.001). Compared to healthy controls, patients with LLD exhibited higher <sup>18</sup>F-flutemetamol SUVR in both NAWM (p<0.001, Cohen's d=0.91) and WMH (p=0.005, d=0.56), even after controlling for age and <sup>18</sup>F-flutemetamol SUVR in cortical gray matter.</p><p><strong>Conclusions: </strong>Our result of elevated <sup>18</sup>F-flutemetamol uptake in NAWM does not align with the pathological neurodegenerative aging pattern observed in Alzheimer's disease but is in line with patterns of age-related changes. This distinction is crucial for the development of future targeted treatments.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Accelerated aging of white matter in late-life depression: evidence from <sup>18</sup>F-flutemetamol PET imaging.\",\"authors\":\"Akihiro Takamiya, Thomas Vande Casteele, Filip Bouckaert, Margot Ga Van Cauwenberge, Maarten Laroy, François-Laurent De Winter, Patrick Dupont, Jan Van den Stock, Michel Koole, Koen Van Laere, Louise Emsell, Mathieu Vandenbulcke\",\"doi\":\"10.1016/j.bpsc.2025.03.013\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Late-life depression (LLD) is associated with white matter (WM) alterations. Current evidence indicates amyloid PET tracers as sensitive and reliable markers for evaluating normal-appearing WM (NAWM) on magnetic resonance imaging (MRI), showing an association between lower uptake and Alzheimer's disease pathology and higher uptake with age-related changes. Utilizing this novel and reliable technique, we aimed to distinguish two hypothetical models for neurobiology of LLD: the pathological neurodegenerative model and the accelerated aging model.</p><p><strong>Methods: </strong>In this monocentric cross-sectional study, a total of 103 participants, including 61 patients with LLD (age 73.8±7.0 years, 41 female) and 42 healthy controls (age 72.5±7.6 years, 28 female), underwent PET imaging with <sup>18</sup>F-flutemetamol, MRI, and clinical assessment. T2-weighted fluid-attenuated inversion recovery (FLAIR) images were segmented into WM hyperintensities (WMH) and NAWM.</p><p><strong>Results: </strong><sup>18</sup>F-flutemetamol standardized uptake value ratio (SUVR) in WMH was significantly lower than that in NAWM (t=7.8, df=102, p<0.001). Compared to healthy controls, patients with LLD exhibited higher <sup>18</sup>F-flutemetamol SUVR in both NAWM (p<0.001, Cohen's d=0.91) and WMH (p=0.005, d=0.56), even after controlling for age and <sup>18</sup>F-flutemetamol SUVR in cortical gray matter.</p><p><strong>Conclusions: </strong>Our result of elevated <sup>18</sup>F-flutemetamol uptake in NAWM does not align with the pathological neurodegenerative aging pattern observed in Alzheimer's disease but is in line with patterns of age-related changes. This distinction is crucial for the development of future targeted treatments.</p>\",\"PeriodicalId\":93900,\"journal\":{\"name\":\"Biological psychiatry. Cognitive neuroscience and neuroimaging\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-04-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biological psychiatry. Cognitive neuroscience and neuroimaging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/j.bpsc.2025.03.013\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biological psychiatry. Cognitive neuroscience and neuroimaging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.bpsc.2025.03.013","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Accelerated aging of white matter in late-life depression: evidence from 18F-flutemetamol PET imaging.
Background: Late-life depression (LLD) is associated with white matter (WM) alterations. Current evidence indicates amyloid PET tracers as sensitive and reliable markers for evaluating normal-appearing WM (NAWM) on magnetic resonance imaging (MRI), showing an association between lower uptake and Alzheimer's disease pathology and higher uptake with age-related changes. Utilizing this novel and reliable technique, we aimed to distinguish two hypothetical models for neurobiology of LLD: the pathological neurodegenerative model and the accelerated aging model.
Methods: In this monocentric cross-sectional study, a total of 103 participants, including 61 patients with LLD (age 73.8±7.0 years, 41 female) and 42 healthy controls (age 72.5±7.6 years, 28 female), underwent PET imaging with 18F-flutemetamol, MRI, and clinical assessment. T2-weighted fluid-attenuated inversion recovery (FLAIR) images were segmented into WM hyperintensities (WMH) and NAWM.
Results: 18F-flutemetamol standardized uptake value ratio (SUVR) in WMH was significantly lower than that in NAWM (t=7.8, df=102, p<0.001). Compared to healthy controls, patients with LLD exhibited higher 18F-flutemetamol SUVR in both NAWM (p<0.001, Cohen's d=0.91) and WMH (p=0.005, d=0.56), even after controlling for age and 18F-flutemetamol SUVR in cortical gray matter.
Conclusions: Our result of elevated 18F-flutemetamol uptake in NAWM does not align with the pathological neurodegenerative aging pattern observed in Alzheimer's disease but is in line with patterns of age-related changes. This distinction is crucial for the development of future targeted treatments.
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