药物性肝损伤。

IF 1.9 3区农林科学 Q2 VETERINARY SCIENCES

Veterinary Clinics of North America-Small Animal Practice Pub Date : 2025-04-24 DOI:10.1016/j.cvsm.2025.03.003

Jennifer M Reinhart

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引用次数: 0

摘要

药物性肝损伤（DILI）是一种未被充分认识的导致狗和猫肝脏疾病的原因。成功识别病例需要从业人员的初步怀疑，彻底的药物暴露史以及对普通兽药潜在毒性的了解。本文综述了小动物DILI的发病机制、分类和诊断。它还讨论了几种重要兽医学药物DILI的临床表现、流行程度和结果，包括硫唑嘌呤、唑类抗真菌药、卡洛芬、地西泮、多西环素、洛莫司汀、甲巯咪唑、苯巴比妥、利福平、磺胺类抗生素和唑尼沙胺，以及营养品和草药制剂的潜在毒性。

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Drug-Induced Liver Injury.

Drug-induced liver injury (DILI) is an underrecognized cause of hepatic disease in dogs and cats. Successful identification of cases requires an initial suspicion by the practitioner, a thorough drug exposure history, and knowledge of the toxic potential for common veterinary drugs. This article reviews the pathogenesis, classification, and diagnosis of DILI in small animals. It also discusses the clinical presentation, prevalence, and outcomes of DILI for several drugs important in veterinary medicine including azathioprine, azole antifungals, carprofen, diazepam, doxycycline, lomustine, methimazole, phenobarbital, rifampin, sulfonamide antibiotics, and zonisamide, as well as the toxic potential for nutraceuticals and herbal preparations.

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来源期刊

Veterinary Clinics of North America-Small Animal Practice 农林科学-兽医学

CiteScore

3.80

自引率

0.00%

发文量

123

审稿时长

18-36 weeks

期刊介绍： Veterinary Clinics of North America: Small Animal Practice offers you the most current information on the treatment of small animals such as cats and dogs, updates you on the latest advances, and provides a sound basis for choosing treatment options. Published bi-monthly—in January, March, May, July, September, November—each issue focuses on a single topic in small animal practice, including endocrinology, fluids and electrolytes, gastroenterology, infectious diseases, neurology, oncology, urology, respiratory issues , surgical information, small animal behavior, laboratory medicine, imaging methods, and nutrition.