脑深部电刺激治疗缺氧后肌阵挛：一个局部场电位与临床结果相关的病例。

IF 2.5 Q2 CLINICAL NEUROLOGY

Tremor and Other Hyperkinetic Movements Pub Date : 2025-04-24 eCollection Date: 2025-01-01 DOI:10.5334/tohm.999

Harleen Kaur, Tim J Goble, Albert Fenoy, Ritesh A Ramdhani

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引用次数: 0

摘要

背景：缺氧后肌阵挛（PHM）以缺氧脑损伤后的全身性肌阵挛为特征。PHM通常功能受损，药物治疗难治。有少数报道利用脑深部电刺激（DBS）治疗难治性PHM。病例报告：一名56岁女性在缺氧脑损伤后发展为PHM。利用刺激和传感DBS系统，我们在6个月时显示肌阵挛的临床改善，并将其与局部场电位（LFP）活动联系起来。讨论：我们提出了第一个利用DBS传感将LFP活性与肌阵挛改善联系起来的病例。我们的案例为PHM的DBS提供了越来越多的证据。

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Deep Brain Stimulation for Post-Hypoxic Myoclonus: A Case Correlating Local Field Potentials to Clinical Outcome.

Background: Post-hypoxic myoclonus (PHM) is characterized by generalized myoclonus after hypoxic brain injury. PHM is often functionally impairing and refractory to medical therapies. There are a handful of reports utilizing deep brain stimulation (DBS) to treat medically refractory PHM.

Case report: A 56-year-old woman developed PHM following an anoxic brain injury. Utilizing a stimulating and sensing DBS system, we show clinical improvement in myoclonus at 6 months and correlate it to local field potential (LFP) activity.

Discussion: We present the first case to utilize DBS sensing to correlate LFP activity to myoclonus improvement. Our case contributes to the growing evidence of DBS for PHM.

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来源期刊

Tremor and Other Hyperkinetic Movements CLINICAL NEUROLOGY-

CiteScore

4.00

自引率

4.50%

发文量

审稿时长

6 weeks