成功的英夫利昔单抗治疗系统性结节病表现为巨大的腿部溃疡：一个案例为基础的回顾。

IF 3.2 3区医学 Q2 RHEUMATOLOGY

Rheumatology International Pub Date : 2025-05-06 DOI:10.1007/s00296-025-05887-3

Nabil Belfeki, Nadia Ghariani Fetoui, Nour El Imene Ouni, Juliette Avci, Renaud Guedec-Ghelfi, Sonia Kammoun, Nouha Ghriss

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引用次数: 0

摘要

结节病是一种慢性肉芽肿性炎症性疾病，主要影响肺部和皮肤。大约30%的病例发生皮肤受累。我们在此报告一个罕见的病例，55岁男性慢性，不愈合的双侧腿溃疡，最终诊断为溃疡性皮肤结节病，通过组织病理学确认。巨大的腿部溃疡合并系统性结节病是罕见的，其管理是具有挑战性的，因为没有具体的建议。在我们的病例中，24个月的静脉注射英夫利昔单抗联合口服强的松诱导了持续的临床缓解。目前的减幅是3年。我们工作的目的是回顾溃疡性皮肤结节病的临床表现和治疗，并将其与文献报道的病例进行比较。

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Successful infliximab therapy in systemic sarcoidosis presenting with giant leg ulcers: a case based review.

Sarcoidosis is a chronic granulomatous inflammatory disease that primarily affects the lungs and skin. Cutaneous involvement occurs in approximately 30% of cases. We report herewith a rare case of a 55-year-old man with chronic, non-healing bilateral leg ulcers, ultimately diagnosed as ulcerative cutaneous sarcoidosis through histopathological confirmation. Giant leg ulcers complicating systemic sarcoidosis is rare and its management is challenging because there are no specific recommendation. In our case, a 24-month course of intravenous infliximab associated with oral prednisone induced sustained clinical remission. The current decline is three years. The aim of our work is to review the clinical presentation and management of ulcerative cutaneous sarcoidosis and compare them to reported cases in literature.

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来源期刊

Rheumatology International 医学-风湿病学

CiteScore

7.30

自引率

5.00%

发文量

191

审稿时长

16. months

期刊介绍： RHEUMATOLOGY INTERNATIONAL is an independent journal reflecting world-wide progress in the research, diagnosis and treatment of the various rheumatic diseases. It is designed to serve researchers and clinicians in the field of rheumatology. RHEUMATOLOGY INTERNATIONAL will cover all modern trends in clinical research as well as in the management of rheumatic diseases. Special emphasis will be given to public health issues related to rheumatic diseases, applying rheumatology research to clinical practice, epidemiology of rheumatic diseases, diagnostic tests for rheumatic diseases, patient reported outcomes (PROs) in rheumatology and evidence on education of rheumatology. Contributions to these topics will appear in the form of original publications, short communications, editorials, and reviews. "Letters to the editor" will be welcome as an enhancement to discussion. Basic science research, including in vitro or animal studies, is discouraged to submit, as we will only review studies on humans with an epidemological or clinical perspective. Case reports without a proper review of the literatura (Case-based Reviews) will not be published. Every effort will be made to ensure speed of publication while maintaining a high standard of contents and production. Manuscripts submitted for publication must contain a statement to the effect that all human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in an appropriate version of the 1964 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study should be omitted.