Haibo Liang, Qihang Wu, Shu Yang, Shuhao Zhang, Jiansen Miao, Haiming Jin, Xiangyang Wang
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We employed inverse variance weighting (IVW), weighted median, and MR-Egger regression methods to assess causal effects. Heterogeneity was evaluated using MR-Egger regression and IVW, while horizontal pleiotropy was assessed using MR-PRESSO analysis and MR-Egger regression.</p><p><strong>Results: </strong>The IVW results showed that major depressive disorder (OR = 1.51, 95% CI: 1.15, 1.98, p = 3.40×10<sup>-3</sup>) and experiencing mood swings (OR = 2.73, 95% CI: 1.57, 4.75, p = 3.86×10<sup>-4</sup>) were positively associated with NP and years of schooling (OR = 0.504, 95% CI: 0.410, 0.619, p = 6.55×10<sup>-11</sup>) was negatively associated with NP. Additionally, loneliness (OR = 16.0, 95% CI: 1.29-198, p = 0.0307) showed a suggestive association with NP. As for the other factors we did not find a clear causal relationship (All p-values > 0.05).</p><p><strong>Conclusion: </strong>This two-sample MR study provides genetic evidence supporting a causal relationship between major depressive disorder, mood swings, and years of schooling with NP, while loneliness showed a potential association. These findings highlight the critical role of psychosocial factors, such as depression, mood swings, and education level, in the prevention and management of NP. Our results may offer new insights for clinicians to develop targeted intervention strategies aimed at reducing the incidence of NP.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2191-2201"},"PeriodicalIF":2.5000,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039842/pdf/","citationCount":"0","resultStr":"{\"title\":\"Causal Relationship Between Psychosocial Factors and Neck Pain: A Two-Sample Mendelian Randomization Study.\",\"authors\":\"Haibo Liang, Qihang Wu, Shu Yang, Shuhao Zhang, Jiansen Miao, Haiming Jin, Xiangyang Wang\",\"doi\":\"10.2147/JPR.S508287\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Neck pain (NP) is a multifactorial disorder that leads to severe disability. This study aimed to investigate whether potential risk factors have a causal effect on NP at the genetic level using a two-sample Mendelian randomization (MR) analysis.</p><p><strong>Methods: </strong>Summary-level data for potential risk factors, including distress, anxiety disorder, depression, mood, sleep disorder, loneliness, education, alcohol consumption, smoking, time spent using the computer, and physical activity, as well as NP, were obtained from multiple large-scale Genome-Wide Association Studies (GWAS). Instrumental variables (IVs) were extracted from these datasets. We employed inverse variance weighting (IVW), weighted median, and MR-Egger regression methods to assess causal effects. Heterogeneity was evaluated using MR-Egger regression and IVW, while horizontal pleiotropy was assessed using MR-PRESSO analysis and MR-Egger regression.</p><p><strong>Results: </strong>The IVW results showed that major depressive disorder (OR = 1.51, 95% CI: 1.15, 1.98, p = 3.40×10<sup>-3</sup>) and experiencing mood swings (OR = 2.73, 95% CI: 1.57, 4.75, p = 3.86×10<sup>-4</sup>) were positively associated with NP and years of schooling (OR = 0.504, 95% CI: 0.410, 0.619, p = 6.55×10<sup>-11</sup>) was negatively associated with NP. Additionally, loneliness (OR = 16.0, 95% CI: 1.29-198, p = 0.0307) showed a suggestive association with NP. As for the other factors we did not find a clear causal relationship (All p-values > 0.05).</p><p><strong>Conclusion: </strong>This two-sample MR study provides genetic evidence supporting a causal relationship between major depressive disorder, mood swings, and years of schooling with NP, while loneliness showed a potential association. 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引用次数: 0
摘要
目的：颈痛（NP）是一种导致严重残疾的多因素疾病。本研究旨在通过双样本孟德尔随机化（MR）分析，探讨潜在的危险因素是否在遗传水平上对NP有因果影响。方法：从多个大规模全基因组关联研究（GWAS）中获得潜在危险因素的汇总数据，包括痛苦、焦虑障碍、抑郁、情绪、睡眠障碍、孤独、教育、饮酒、吸烟、使用电脑的时间、身体活动以及NP。从这些数据集中提取工具变量（IVs）。我们采用反方差加权（IVW）、加权中位数和MR-Egger回归方法来评估因果关系。采用MR-Egger回归和IVW评估异质性，而采用MR-PRESSO分析和MR-Egger回归评估水平多效性。结果：IVW结果显示，重度抑郁症（OR = 1.51, 95% CI: 1.15, 1.98, p = 3.40×10-3）和情绪波动（OR = 2.73, 95% CI: 1.57, 4.75, p = 3.86×10-4）与NP呈正相关，受教育年限（OR = 0.504, 95% CI: 0.410, 0.619, p = 6.55×10-11）与NP负相关。此外，孤独感（OR = 16.0, 95% CI: 1.29-198, p = 0.0307）与NP有关联。至于其他因素，我们没有发现明显的因果关系（p值均为0.05）。结论：这项双样本磁共振研究提供了遗传证据，支持重度抑郁症、情绪波动和受教育年限与NP之间的因果关系，而孤独感则显示出潜在的关联。这些发现强调了心理社会因素，如抑郁、情绪波动和教育水平，在NP的预防和管理中的关键作用。我们的研究结果可能为临床医生制定旨在降低NP发病率的有针对性的干预策略提供新的见解。
Causal Relationship Between Psychosocial Factors and Neck Pain: A Two-Sample Mendelian Randomization Study.
Purpose: Neck pain (NP) is a multifactorial disorder that leads to severe disability. This study aimed to investigate whether potential risk factors have a causal effect on NP at the genetic level using a two-sample Mendelian randomization (MR) analysis.
Methods: Summary-level data for potential risk factors, including distress, anxiety disorder, depression, mood, sleep disorder, loneliness, education, alcohol consumption, smoking, time spent using the computer, and physical activity, as well as NP, were obtained from multiple large-scale Genome-Wide Association Studies (GWAS). Instrumental variables (IVs) were extracted from these datasets. We employed inverse variance weighting (IVW), weighted median, and MR-Egger regression methods to assess causal effects. Heterogeneity was evaluated using MR-Egger regression and IVW, while horizontal pleiotropy was assessed using MR-PRESSO analysis and MR-Egger regression.
Results: The IVW results showed that major depressive disorder (OR = 1.51, 95% CI: 1.15, 1.98, p = 3.40×10-3) and experiencing mood swings (OR = 2.73, 95% CI: 1.57, 4.75, p = 3.86×10-4) were positively associated with NP and years of schooling (OR = 0.504, 95% CI: 0.410, 0.619, p = 6.55×10-11) was negatively associated with NP. Additionally, loneliness (OR = 16.0, 95% CI: 1.29-198, p = 0.0307) showed a suggestive association with NP. As for the other factors we did not find a clear causal relationship (All p-values > 0.05).
Conclusion: This two-sample MR study provides genetic evidence supporting a causal relationship between major depressive disorder, mood swings, and years of schooling with NP, while loneliness showed a potential association. These findings highlight the critical role of psychosocial factors, such as depression, mood swings, and education level, in the prevention and management of NP. Our results may offer new insights for clinicians to develop targeted intervention strategies aimed at reducing the incidence of NP.
期刊介绍：
Journal of Pain Research is an international, peer-reviewed, open access journal that welcomes laboratory and clinical findings in the fields of pain research and the prevention and management of pain. Original research, reviews, symposium reports, hypothesis formation and commentaries are all considered for publication. Additionally, the journal now welcomes the submission of pain-policy-related editorials and commentaries, particularly in regard to ethical, regulatory, forensic, and other legal issues in pain medicine, and to the education of pain practitioners and researchers.
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