晚年抑郁症患者情绪冲突加工中的瞳孔和眨眼反应异常。

IF 2.9 4区 医学 Q2 CLINICAL NEUROLOGY
Yao-Tung Lee, Yi-Hsuan Chang, Cesar Barquero, Chi-Shin Wu, Shu-Ping Chao, David Yen-Ting Chen, Jui-Tai Chen, Yih-Giun Cherng, Chin-An Wang
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引用次数: 0

摘要

本研究旨在通过研究任务诱发瞳孔扩张与LC-NE激活之间的耦合,探讨晚年抑郁症(LLD)患者蓝斑-去甲肾上腺素系统(LC-NE)的功能。材料与方法采用基于视频的眼动追踪和主成分分析,探讨了LLD患者(N = 25)和老年健康对照(N = 29)的任务诱发瞳孔反应和眨眼,以确定LLD患者的瞳孔反应和眨眼与对照组相比是否有改变。结果与对照组相比,slld组的瞳孔和眨眼行为有显著差异,与交感神经系统介导的情绪一致性和效价加工相关的任务诱发瞳孔扩张受到抑制。与对照组相比,LLD组与情绪效价相关的眨眼率也发生了变化。此外,LLD组的老年抑郁量表-15得分与任务诱发瞳孔扩张所显示的情绪一致性效应相关。结论LLD患者瞳孔行为与对照组相比有明显改变。这些改变的反应与抑郁症状的严重程度相关,表明它们有潜力作为LLD大量高危人群的客观生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pupil and Eye Blink Response Abnormalities During Emotional Conflict Processing in Late-Life Depression.

IntroductionThis study aims to investigate the locus coeruleus-norepinephrine system (LC-NE) function in late-life depression (LLD) patients by examining task-evoked pupil dilation in the emotional face-word Stroop task, given the recently established coupling between task-evoked pupil dilation and LC-NE activation.Materials and MethodsUsing video-based eye-tracking and principal component analysis, we explored task-evoked pupil responses and eye blinks in LLD patients (N = 25) and older healthy controls (CTRL) (N = 29) to determine whether there were alterations in pupil responses and eye blinks in LLD compared to CTRL.ResultsLLD patients exhibited significantly different pupil and eye-blink behavior compared to CTRL, with dampened task-evoked pupil dilation associated with emotional congruency and valence processing mediated by the sympathetic system compared to CTRL. Eye-blink rates associated with emotional valence were also altered in LLD compared to CTRL Moreover, Geriatric Depression Scale-15 scores in LLD correlated with emotional congruency effects revealed by task-evoked pupil dilation.ConclusionThe findings demonstrate that LLD patients display altered pupil behavior compared to CTRL. These altered responses correlated with the severity of depressive symptoms, indicating their potential as objective biomarkers for use in large at-risk populations for LLD.

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来源期刊
CiteScore
6.20
自引率
0.00%
发文量
40
审稿时长
>12 weeks
期刊介绍: Journal of Geriatric Psychiatry and Neurology (JGP) brings together original research, clinical reviews, and timely case reports on neuropsychiatric care of aging patients, including age-related biologic, neurologic, and psychiatric illnesses; psychosocial problems; forensic issues; and family care. The journal offers the latest peer-reviewed information on cognitive, mood, anxiety, addictive, and sleep disorders in older patients, as well as tested diagnostic tools and therapies.
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