胰高血糖素样肽-1 （GLP-1）受体激动剂的使用和手术患者肺误吸的风险

IF 12.5 2区医学 Q1 SURGERY

International journal of surgery Pub Date : 2025-05-12 DOI:10.1097/JS9.0000000000002425

Jason D Wright, Ling Chen, Xiao Xu, Chin Hur, Koji Matsuo, Elena B Elkin, Dawn L Hershman

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引用次数: 0

摘要

胰高血糖素样肽-1 （GLP-1）受体激动剂被批准用于治疗II型糖尿病和肥胖症。这些药物减缓胃排空，并可能增加肺误吸的风险，特别是在接受择期手术的患者中。我们使用索赔数据库来检查围手术期GLP-1受体激动剂使用与肺误吸风险之间的关系。共有392065例患者接受择期手术，其中15745例（4.0%）使用GLP-1受体激动剂。接受GLP-1受体激动剂治疗的患者肺误吸率为0.8%，未接受GLP-1受体激动剂治疗的患者为0.7% （P = 0.61）。在校正误吸的其他危险因素后，GLP-1激动剂的使用与误吸之间没有关联(OR = 1.07；95% ci, 0.85-1.34)。

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Glucagon-like-peptide-1 (GLP-1) receptor agonist use and the risk of pulmonary aspiration in patients undergoing surgery.

Glucagon-like-peptide-1 (GLP-1) receptor agonists are approved for the treatment of type II diabetes mellitus and obesity. These agents slow gastric emptying and may increase the risk of pulmonary aspiration, particularly in patients undergoing elective surgery. We used a claims database to examine the association between perioperative GLP-1 receptor agonist use and the risk of pulmonary aspiration. A total of 392 065 patients including 15 745 (4.0%) who used GLP-1 receptor agonist who underwent elective surgery were identified. The rate of pulmonary aspiration was 0.8% in those who received GLP-1 receptor agonists versus 0.7% in those who had not (P = 0.61). After adjusting for other risk factors for aspiration, there was no association between GLP-1 agonist use and aspiration (OR = 1.07; 95% CI, 0.85-1.34).

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来源期刊

International journal of surgery SURGERY-

CiteScore

17.70

自引率

3.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The International Journal of Surgery (IJS) has a broad scope, encompassing all surgical specialties. Its primary objective is to facilitate the exchange of crucial ideas and lines of thought between and across these specialties.By doing so, the journal aims to counter the growing trend of increasing sub-specialization, which can result in "tunnel-vision" and the isolation of significant surgical advancements within specific specialties.