{"title":"外耳道癌的当前治疗策略。","authors":"Hirotaka Shinomiya, Takeshi Fujita, Ken-Ichi Nibu","doi":"10.1093/jjco/hyaf058","DOIUrl":null,"url":null,"abstract":"<p><p>Auditory canal cancer is a rare form of carcinoma, making it extremely challenging to establish standard treatments through prospective studies. To date, no prospective comparative trials have been conducted, and standard treatment protocols have largely been derived from meta-analyses of case series. Several controversies remain unresolved, including the necessity of prophylactic neck dissection, the criteria for postoperative radiotherapy, and the choice between surgical treatment and chemoradiotherapy for advanced cases. These questions remain difficult to address owing to the rarity of the disease. This article aims to review the existing literature on external auditory canal squamous cell carcinoma, summarize current knowledge, and highlight areas for future research. Early-stage cancers have a favorable prognosis, with surgical treatment and postoperative radiotherapy serving as standard approaches for high-risk groups. The treatment of advanced-stage cancer remains challenging, although oncological outcomes have improved over time. Surgery combined with postoperative radiotherapy is commonly used; however, studies have shown no significant difference in prognosis compared with definitive chemoradiotherapy. Treatment strategies should be tailored to each individual case, with careful consideration of quality of life. Outcomes for inoperable cases remain extremely poor, highlighting the urgent need for new therapeutic strategies.</p>","PeriodicalId":14656,"journal":{"name":"Japanese journal of clinical oncology","volume":" ","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Current treatment strategies for external auditory canal cancer.\",\"authors\":\"Hirotaka Shinomiya, Takeshi Fujita, Ken-Ichi Nibu\",\"doi\":\"10.1093/jjco/hyaf058\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Auditory canal cancer is a rare form of carcinoma, making it extremely challenging to establish standard treatments through prospective studies. To date, no prospective comparative trials have been conducted, and standard treatment protocols have largely been derived from meta-analyses of case series. Several controversies remain unresolved, including the necessity of prophylactic neck dissection, the criteria for postoperative radiotherapy, and the choice between surgical treatment and chemoradiotherapy for advanced cases. These questions remain difficult to address owing to the rarity of the disease. This article aims to review the existing literature on external auditory canal squamous cell carcinoma, summarize current knowledge, and highlight areas for future research. Early-stage cancers have a favorable prognosis, with surgical treatment and postoperative radiotherapy serving as standard approaches for high-risk groups. The treatment of advanced-stage cancer remains challenging, although oncological outcomes have improved over time. Surgery combined with postoperative radiotherapy is commonly used; however, studies have shown no significant difference in prognosis compared with definitive chemoradiotherapy. Treatment strategies should be tailored to each individual case, with careful consideration of quality of life. Outcomes for inoperable cases remain extremely poor, highlighting the urgent need for new therapeutic strategies.</p>\",\"PeriodicalId\":14656,\"journal\":{\"name\":\"Japanese journal of clinical oncology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-04-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Japanese journal of clinical oncology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/jjco/hyaf058\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Japanese journal of clinical oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/jjco/hyaf058","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
Current treatment strategies for external auditory canal cancer.
Auditory canal cancer is a rare form of carcinoma, making it extremely challenging to establish standard treatments through prospective studies. To date, no prospective comparative trials have been conducted, and standard treatment protocols have largely been derived from meta-analyses of case series. Several controversies remain unresolved, including the necessity of prophylactic neck dissection, the criteria for postoperative radiotherapy, and the choice between surgical treatment and chemoradiotherapy for advanced cases. These questions remain difficult to address owing to the rarity of the disease. This article aims to review the existing literature on external auditory canal squamous cell carcinoma, summarize current knowledge, and highlight areas for future research. Early-stage cancers have a favorable prognosis, with surgical treatment and postoperative radiotherapy serving as standard approaches for high-risk groups. The treatment of advanced-stage cancer remains challenging, although oncological outcomes have improved over time. Surgery combined with postoperative radiotherapy is commonly used; however, studies have shown no significant difference in prognosis compared with definitive chemoradiotherapy. Treatment strategies should be tailored to each individual case, with careful consideration of quality of life. Outcomes for inoperable cases remain extremely poor, highlighting the urgent need for new therapeutic strategies.
期刊介绍:
Japanese Journal of Clinical Oncology is a multidisciplinary journal for clinical oncologists which strives to publish high quality manuscripts addressing medical oncology, clinical trials, radiology, surgery, basic research, and palliative care. The journal aims to contribute to the world"s scientific community with special attention to the area of clinical oncology and the Asian region.
JJCO publishes various articles types including:
・Original Articles
・Case Reports
・Clinical Trial Notes
・Cancer Genetics Reports
・Epidemiology Notes
・Technical Notes
・Short Communications
・Letters to the Editors
・Solicited Reviews