外耳道癌的当前治疗策略。

IF 1.9 4区 医学 Q3 ONCOLOGY
Hirotaka Shinomiya, Takeshi Fujita, Ken-Ichi Nibu
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引用次数: 0

摘要

听道癌是一种罕见的癌症,通过前瞻性研究建立标准治疗方法极具挑战性。迄今为止,尚未进行前瞻性比较试验,标准治疗方案主要来自病例系列的荟萃分析。一些争议仍未解决,包括预防性颈部清扫的必要性,术后放疗的标准,以及晚期病例手术治疗和放化疗的选择。由于该病罕见,这些问题仍然难以解决。本文旨在综述外耳道鳞状细胞癌的现有文献,总结现有知识,并指出未来的研究领域。早期癌症预后良好,手术治疗和术后放疗是高危人群的标准治疗方法。尽管肿瘤预后随着时间的推移有所改善,但晚期癌症的治疗仍然具有挑战性。常用手术联合术后放疗;然而,研究表明,与明确的放化疗相比,预后无显著差异。治疗策略应根据每个病例量身定制,并仔细考虑生活质量。无法手术病例的预后仍然非常差,这突出了迫切需要新的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Current treatment strategies for external auditory canal cancer.

Auditory canal cancer is a rare form of carcinoma, making it extremely challenging to establish standard treatments through prospective studies. To date, no prospective comparative trials have been conducted, and standard treatment protocols have largely been derived from meta-analyses of case series. Several controversies remain unresolved, including the necessity of prophylactic neck dissection, the criteria for postoperative radiotherapy, and the choice between surgical treatment and chemoradiotherapy for advanced cases. These questions remain difficult to address owing to the rarity of the disease. This article aims to review the existing literature on external auditory canal squamous cell carcinoma, summarize current knowledge, and highlight areas for future research. Early-stage cancers have a favorable prognosis, with surgical treatment and postoperative radiotherapy serving as standard approaches for high-risk groups. The treatment of advanced-stage cancer remains challenging, although oncological outcomes have improved over time. Surgery combined with postoperative radiotherapy is commonly used; however, studies have shown no significant difference in prognosis compared with definitive chemoradiotherapy. Treatment strategies should be tailored to each individual case, with careful consideration of quality of life. Outcomes for inoperable cases remain extremely poor, highlighting the urgent need for new therapeutic strategies.

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来源期刊
CiteScore
3.70
自引率
8.30%
发文量
177
审稿时长
3-8 weeks
期刊介绍: Japanese Journal of Clinical Oncology is a multidisciplinary journal for clinical oncologists which strives to publish high quality manuscripts addressing medical oncology, clinical trials, radiology, surgery, basic research, and palliative care. The journal aims to contribute to the world"s scientific community with special attention to the area of clinical oncology and the Asian region. JJCO publishes various articles types including: ・Original Articles ・Case Reports ・Clinical Trial Notes ・Cancer Genetics Reports ・Epidemiology Notes ・Technical Notes ・Short Communications ・Letters to the Editors ・Solicited Reviews
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