生物材料的低温保存:应用和经济前景。

IF 1.5 4区 生物学 Q4 CELL BIOLOGY
Suja Aarattuthodi, David Kang, Sanjay Kumar Gupta, Paula Chen, Bethany Redel, Moureen Matuha, Haitham Mohammed, Amit Kumar Sinha
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引用次数: 0

摘要

低温保存是一种变革性的技术,通过将生物材料冷却到极低的温度,从而有效地减缓或停止代谢和生化过程,从而实现生物材料的长期储存。低温保存利用各种技术来减少冰晶的形成和细胞在冷冻和解冻过程中的损伤。这项技术在医学、农业和保护领域有着广泛的应用,跨越了干细胞研究、生殖和再生医学、器官移植和基于细胞的治疗,每一项都具有重要的经济意义。虽然目前的技术及其相关成本存在一定的挑战,但与冷冻保护剂、冷却方法和自动化相关的持续研究进展有望提高效率和可及性,潜在地扩大技术在各个领域的影响。本文综述了低温保存的应用、研究进展和经济意义,强调了继续研究以克服当前局限性的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cryopreservation of biological materials: applications and economic perspectives.

Cryopreservation is a transformative technology that allows for the long-term storage of biological materials by cooling them to extremely low temperatures at which metabolic and biochemical processes are effectively slowed or halted. Cryopreservation utilizes various techniques to minimize ice crystal formation and cellular damage during freezing and thawing processes. This technology has broad applications in the fields of medicine, agriculture, and conservation, spanning across stem cell research, reproductive and regenerative medicine, organ transplantation, and cell-based therapies, each with significant economic implications. While current techniques and their associated costs present certain challenges, ongoing research advancements related to cryoprotectants, cooling methods, and automation promise to enhance efficiency and accessibility, potentially broadening the technology's impact across various sectors. This review focuses on the applications of cryopreservation, research advancements, and economic implications, emphasizing the importance of continued research to overcome the current limitations.

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来源期刊
CiteScore
3.70
自引率
4.80%
发文量
96
审稿时长
3 months
期刊介绍: In Vitro Cellular & Developmental Biology - Animal is a journal of the Society for In Vitro Biology (SIVB). Original manuscripts reporting results of research in cellular, molecular, and developmental biology that employ or are relevant to organs, tissue, tumors, and cells in vitro will be considered for publication. Topics covered include: Biotechnology; Cell and Tissue Models; Cell Growth/Differentiation/Apoptosis; Cellular Pathology/Virology; Cytokines/Growth Factors/Adhesion Factors; Establishment of Cell Lines; Signal Transduction; Stem Cells; Toxicology/Chemical Carcinogenesis; Product Applications.
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