跨越脊髓损伤的死亡之谷:向成功译者学习。

IF 1.8 Q3 CLINICAL NEUROLOGY
Neurotrauma reports Pub Date : 2025-04-14 eCollection Date: 2025-01-01 DOI:10.1089/neur.2025.0029
Vieri Failli, Stephen M Strittmatter, Martin E Schwab, Aileen J Anderson, Angela Ruban, Hassan Al-Ali, Armin Curt, Adrien Cohen, Jane T C Hsieh
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引用次数: 0

摘要

通往成功的科学翻译的直接途径仍然未知,特别是在复杂的进行性疾病中,如脊髓损伤(SCI),它同时影响多种身体功能。不断变化的监管要求增加了获得既安全又有效的治疗的复杂性和费用。虽然罕见,但也有SCI科学家成功地从发现科学到完成临床试验的“死亡之谷”。这篇文章反映了五位SCI科学家在努力启动或完成临床试验的过程中遇到的相似或不同的情况。从这些经验中,我们发现了经验教训和差距,特别是在SCI翻译的资助和支持方面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Crossing the Valley of Death in Spinal Cord Injury: Learning from Successful Translators.

A straightforward path to successful scientific translation remains uncharted, particularly in a complex progressive condition such as spinal cord injury (SCI), which affects multiple body functions simultaneously. Evolving regulatory requirements add to the complexity and expense of attaining a treatment that is both safe and efficacious. Although rare, there are examples of SCI scientists who have successfully navigated the "valley of death" from discovery science to completed clinical trials. This article reflects the translational journey of five SCI scientists who have encountered similar and different scenarios while striving to launch or complete a clinical trial. Learning from these experiences has identified lessons learned and gaps, particularly with respect to funding and support for SCI translation.

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来源期刊
CiteScore
2.40
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0.00%
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审稿时长
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