99mTc-FAPI-46 SPECT/CT在特发性腹膜后纤维化评估中的应用：一个新的有希望的经验的病例报告。

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical Nuclear Medicine Pub Date : 2025-05-09 DOI:10.1097/RLU.0000000000005875

Nasrin Raeisi, Amin Saber Tanha, Ehsan Soltani, Kamran Aryana, Atena Aghaee

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引用次数: 0

摘要

这个病例报告描述了一个59岁的男性疲劳和双侧下肢水肿，诊断为腹膜后纤维化（RPF）。实验室检查显示血清肌酐、ESR和CRP水平升高，同时影像学显示左侧输尿管积水和骨盆肿块包围髂血管。活检显示纤维化改变，无恶性，证实RPF。使用99mTc-FAPI-46作为一种新型的常规成像试剂的经验表明，RPF具有很高的靶本比，表明其在诊断和评估疾病活动性方面的实用性，也有助于排除远处恶性肿瘤，特别是在PET/CT不可用的情况下。

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Application of 99mTc-FAPI-46 SPECT/CT in Evaluation of Idiopathic Retroperitoneal Fibrosis: Case Report of a Novel Promising Experience.

This case report describes a 59-year-old man with fatigue and bilateral lower limb edema, diagnosed with retroperitoneal fibrosis (RPF). Laboratory tests showed elevated serum creatinine, ESR, and CRP levels, while imaging revealed left hydroureteronephrosis and a pelvic mass encasing the iliac vessels. A biopsy indicated fibrotic changes without malignancy, confirming RPF. This experience of using 99mTc-FAPI-46 as a novel agent for conventional imaging demonstrated a high target-to-background ratio in the RPF, suggesting its utility in diagnosis and assessing disease activity, also aiding in ruling out the distant malignant neoplasms, especially where PET/CT is not available.

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.