不同治疗方式下青少年特发性关节炎患者的流感疫苗接种:安全性和免疫反应。

IF 2.8 3区 医学 Q1 PEDIATRICS
Adam Gyori, Arnold Nagy, Gabor Ottoffy, Tamas Decsi, Diana Simon, Timea Berki, Timea Dergez, David Kuti, Bernadett Mosdosi
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引用次数: 0

摘要

背景:风湿病儿童建议每年接种流感疫苗。我们研究了接种灭活流感疫苗的儿科患者的细胞和体液免疫反应和安全性。方法:对41例青少年特发性关节炎(JIA)患儿进行比较研究,接种流感疫苗同时接受甲氨蝶呤(MTX)或生物治疗。流感疫苗接种为单剂三价流感疫苗(TIV)。在基线和接种后4周和12周进行血清学检测以监测血清转化和血清保护。结果:在41例JIA患儿和22例健康儿童中,均观察到甲型流感的血清转化和血清保护。对于乙型流感,在所有研究组中均未检测到足够的血清转化率。同时分析时间点和组时,淋巴细胞亚群无显著差异。接种后没有流感复发或感染病例。根据所调查的淋巴细胞亚群的分布和数量,我们的研究结果并不表明接种疫苗后存在非特异性免疫激活。结论:本研究表明免疫抑制的JIA患儿对甲型流感有足够的血清保护作用。三价疫苗具有良好的免疫原性,在JIA治疗组中均可安全使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Influenza vaccination in patients with juvenile idiopathic arthritis under different treatments: safety and immune response.

Background: Annual flu vaccination is recommended for children with rheumatic diseases. We investigated the cellular and humoral immune response and safety in pediatric patients that received inactivated influenza vaccines.

Methods: This is a comparative study of in 41 children with juvenile idiopathic arthritis (JIA) receiving influenza vaccination while being treated with methotrexate (MTX) or biological therapy. The influenza vaccination was administered as a single dose of trivalent influenza vaccine (TIV). Serological tests to monitor seroconversion and seroprotection were performed at baseline and at 4 as well as 12 weeks after vaccination.

Results: In all of the 41 children with JIA and the 22 healthy children seroconversion and seroprotection were observed for Influenza A. For Influenza B, no adequate seroconversion rates were not detected in any of the groups studied. No significant differences were observed in lymphocyte subpopulations when analysing time points and groups simultaneously. There were no relapses or cases of influenza infection after the vaccination. Our findings do not suggest non-specific immune activation following vaccination based on the distribution and quantity of the lymphocyte subsets that were investigated.

Conclusion: The present study demonstrates adequate seroprotection rates against influenza A in immunosuppressed children with JIA. The trivalent vaccine had good immunogenicity and was safe to use in both JIA treatment groups.

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来源期刊
Pediatric Rheumatology
Pediatric Rheumatology PEDIATRICS-RHEUMATOLOGY
CiteScore
4.10
自引率
8.00%
发文量
95
审稿时长
>12 weeks
期刊介绍: Pediatric Rheumatology is an open access, peer-reviewed, online journal encompassing all aspects of clinical and basic research related to pediatric rheumatology and allied subjects. The journal’s scope of diseases and syndromes include musculoskeletal pain syndromes, rheumatic fever and post-streptococcal syndromes, juvenile idiopathic arthritis, systemic lupus erythematosus, juvenile dermatomyositis, local and systemic scleroderma, Kawasaki disease, Henoch-Schonlein purpura and other vasculitides, sarcoidosis, inherited musculoskeletal syndromes, autoinflammatory syndromes, and others.
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