子痫前期子宫灌注压降低模型大鼠胎盘微观结构的同差k分布时间表征。

IF 2.4 3区医学 Q2 ACOUSTICS

Ultrasound in Medicine and Biology Pub Date : 2025-04-15 DOI:10.1016/j.ultrasmedbio.2025.03.007

Alexander D. Gleed , Andrew C. Markel , Lili Shi , Allan K.N. Alencar , Kenneth F. Swan , Cameron Hoerig , Gabriella C. Pridjian , Carolyn L. Bayer , Jonathan Mamou

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引用次数: 0

摘要

目的：利用同差k分布参数化体内超声射频回波帧包络检测信号，表征子痫前期子宫灌注压降低（RUPP）模型下大鼠胎盘微观结构。子痫前期是一种危及生命的妊娠综合征，与胎盘组织微观结构异常有关，这促使了本研究中使用的基于定量超声的组织表征方法。方法：选取9只Sprague-Dawley大鼠，在妊娠14天和18天分别对30颗和38颗体内胎盘进行超声射频随时间回波帧（或视频）采集。在RUPP模型后（GD 14后）通过手术修饰诱导子痫前期样效应，在GD 18时共给予20个RUPP和18个对照胎盘。同差k分布拟合超声射频回波帧包络检测信号随时间的值分布，得到用于表征胎盘组织微观结构的时间参数α（每个分辨率细胞的散射体数）和κ（相干与漫射信号功率之比）。结果：GD 18 α值在b超影像上以彩色叠加显示，与RUPP相比，控制值更高。使用胎盘水平峰度值，RUPP的平均峰度为4.07±0.71，对照组为5.08±1.28 （p = 0.0044）。在GD 14胎盘中没有观察到显著差异，与预期一致。此外，我们用支持早期发现的帧级统计数据可视化和量化了GD 18 α值的时间变化。结论：本研究利用同差k分布和时间α、κ参数定量表征了大鼠胎盘的微观结构。

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Homodyned K-Distribution Temporal-Based Characterization of Rat Placenta Microstructure Using the Reduced Uterine Perfusion Pressure Model of Preeclampsia

Objective

We characterize rat placenta microstructure in the context of the reduced uterine perfusion pressure (RUPP) model of preeclampsia using the homodyned K-distribution to parameterize envelope-detected signals of ultrasound radiofrequency echo frames obtained in vivo. Preeclampsia is a life-threatening pregnancy syndrome related to abnormal placental tissue microstructure which motivated the quantitative ultrasound-based tissue characterization approach used in this study.

Methods

Ultrasound radiofrequency echo frames against time (or videos) were obtained on 30 and 38 in vivo placentae at gestation day (GD) 14 and 18 respectively, using 9 Sprague-Dawley rats. Preeclampsia–like effects were induced by surgical modification (post GD 14) following the RUPP model, giving a total of 20 RUPP and 18 control placentae at GD 18. The homodyned K-distribution was fit to value distributions of envelope-detected signals of ultrasound radiofrequency echo frames against time, yielding temporal α (scatterer number per resolution cell) and κ (ratio of coherent to diffuse signal power) parameters used to characterize the placental tissue microstructure.

Results

Visualization of GD 18 α values as a color overlay on B-mode ultrasound video suggested higher values of control compared with RUPP. The mean kurtosis for RUPP was 4.07 ± 0.71 in comparison to 5.08 ± 1.28 for the control using placenta-level kurtosis values (p = 0.0044). There were no significant differences observed in GD 14 placentae, consistent with expectations. Further, we visualized and quantified temporal changes in GD 18 α values with frame-level statistics that support earlier findings.

Conclusions

This study quantitatively characterizes rat placenta microstructure using the homodyned K-distribution and temporal α and κ parameters.

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来源期刊

Ultrasound in Medicine and Biology 医学-核医学

CiteScore

6.20

自引率

6.90%

发文量

325

审稿时长

70 days

期刊介绍： Ultrasound in Medicine and Biology is the official journal of the World Federation for Ultrasound in Medicine and Biology. The journal publishes original contributions that demonstrate a novel application of an existing ultrasound technology in clinical diagnostic, interventional and therapeutic applications, new and improved clinical techniques, the physics, engineering and technology of ultrasound in medicine and biology, and the interactions between ultrasound and biological systems, including bioeffects. Papers that simply utilize standard diagnostic ultrasound as a measuring tool will be considered out of scope. Extended critical reviews of subjects of contemporary interest in the field are also published, in addition to occasional editorial articles, clinical and technical notes, book reviews, letters to the editor and a calendar of forthcoming meetings. It is the aim of the journal fully to meet the information and publication requirements of the clinicians, scientists, engineers and other professionals who constitute the biomedical ultrasonic community.