{"title":"ARID5A在心脏老化过程中促进炎症和纤维化。","authors":"Shoval Miyara, Eldad Tzahor","doi":"10.1038/s44161-025-00621-5","DOIUrl":null,"url":null,"abstract":"A systematic biology approach identifies an RNA-binding protein, ARID5A, as a regulator of inflammation and fibrosis in the aging human heart. Inhibition of ARID5A reduced inflammation and fibrosis and improved cardiac function in old mice.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"4 5","pages":"508-510"},"PeriodicalIF":10.8000,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"ARID5A promotes inflammation and fibrosis during cardiac aging\",\"authors\":\"Shoval Miyara, Eldad Tzahor\",\"doi\":\"10.1038/s44161-025-00621-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A systematic biology approach identifies an RNA-binding protein, ARID5A, as a regulator of inflammation and fibrosis in the aging human heart. Inhibition of ARID5A reduced inflammation and fibrosis and improved cardiac function in old mice.\",\"PeriodicalId\":74245,\"journal\":{\"name\":\"Nature cardiovascular research\",\"volume\":\"4 5\",\"pages\":\"508-510\"},\"PeriodicalIF\":10.8000,\"publicationDate\":\"2025-04-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature cardiovascular research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s44161-025-00621-5\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature cardiovascular research","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44161-025-00621-5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
ARID5A promotes inflammation and fibrosis during cardiac aging
A systematic biology approach identifies an RNA-binding protein, ARID5A, as a regulator of inflammation and fibrosis in the aging human heart. Inhibition of ARID5A reduced inflammation and fibrosis and improved cardiac function in old mice.
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