癫痫诊断后情绪障碍的风险:韩国一项全国性回顾性队列研究

IF 1.3 4区 医学 Q4 PSYCHIATRY
Youngoh Bae, Chaeyoon Kang, Unbi Choi, Hohyun Jung, Seung Won Lee
{"title":"癫痫诊断后情绪障碍的风险:韩国一项全国性回顾性队列研究","authors":"Youngoh Bae, Chaeyoon Kang, Unbi Choi, Hohyun Jung, Seung Won Lee","doi":"10.1177/00912174251336045","DOIUrl":null,"url":null,"abstract":"<p><p>ObjectiveEpilepsy is a globally prevalent neurological condition associated with mood disorders such as depression and bipolar disorder. This study analyzed the prevalence of and hazard ratios for mood disorders, as well as risk factors, among patients with newly diagnosed epilepsy using a comprehensive South Korean national health database.MethodHealth insurance and health examination data (2004-2013) were utilized in this retrospective cohort study. Patients newly diagnosed with epilepsy based on International Classification of Diseases-10th revision codes and without a mood disorder history were included. Mean follow-up duration was 3.6 years and 4.1 years for the epilepsy and control cohorts, respectively. Cox proportional hazards models adjusted for demographic and health variables were used to estimate the risk of developing mood disorders post-epilepsy diagnosis.ResultsA total of 2210 patients with epilepsy and 22,100 matched controls without epilepsy were included. Those with epilepsy exhibited a 3-fold increased risk of developing mood disorders compared with controls (incidence rate ratio: 3.10 [95% confidence interval (CI): 2.75-3.49]). The risk was highest in the first two years post-diagnosis (adjusted hazard ratio: 3.42 [95% CI: 2.90-4.03]). A notable increase in risk was also observed 8-10 years post-diagnosis (adjusted hazard ratio: 3.07 [(95% CI: 1.14-8.22]), indicating a sustained long-term risk.ConclusionsEpilepsy significantly increases the risk of mood disorders, with the highest risk observed shortly after diagnosis. Continuous monitoring and tailored interventions are essential for managing patients' mental health. Integrated care approaches are needed to treat epilepsy and associated mood disorders.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"662-680"},"PeriodicalIF":1.3000,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Risk of mood disorders after epilepsy diagnosis: A nationwide retrospective cohort study in South Korea.\",\"authors\":\"Youngoh Bae, Chaeyoon Kang, Unbi Choi, Hohyun Jung, Seung Won Lee\",\"doi\":\"10.1177/00912174251336045\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>ObjectiveEpilepsy is a globally prevalent neurological condition associated with mood disorders such as depression and bipolar disorder. This study analyzed the prevalence of and hazard ratios for mood disorders, as well as risk factors, among patients with newly diagnosed epilepsy using a comprehensive South Korean national health database.MethodHealth insurance and health examination data (2004-2013) were utilized in this retrospective cohort study. Patients newly diagnosed with epilepsy based on International Classification of Diseases-10th revision codes and without a mood disorder history were included. Mean follow-up duration was 3.6 years and 4.1 years for the epilepsy and control cohorts, respectively. Cox proportional hazards models adjusted for demographic and health variables were used to estimate the risk of developing mood disorders post-epilepsy diagnosis.ResultsA total of 2210 patients with epilepsy and 22,100 matched controls without epilepsy were included. Those with epilepsy exhibited a 3-fold increased risk of developing mood disorders compared with controls (incidence rate ratio: 3.10 [95% confidence interval (CI): 2.75-3.49]). The risk was highest in the first two years post-diagnosis (adjusted hazard ratio: 3.42 [95% CI: 2.90-4.03]). A notable increase in risk was also observed 8-10 years post-diagnosis (adjusted hazard ratio: 3.07 [(95% CI: 1.14-8.22]), indicating a sustained long-term risk.ConclusionsEpilepsy significantly increases the risk of mood disorders, with the highest risk observed shortly after diagnosis. Continuous monitoring and tailored interventions are essential for managing patients' mental health. Integrated care approaches are needed to treat epilepsy and associated mood disorders.</p>\",\"PeriodicalId\":50294,\"journal\":{\"name\":\"International Journal of Psychiatry in Medicine\",\"volume\":\" \",\"pages\":\"662-680\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Psychiatry in Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/00912174251336045\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/15 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Psychiatry in Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/00912174251336045","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/15 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 0

摘要

目的癫痫是一种全球流行的神经系统疾病,与抑郁症和双相情感障碍等情绪障碍密切相关。本研究利用韩国国家综合健康数据,分析了新诊断癫痫患者的情绪障碍患病率和风险比,以及风险因素。方法回顾性队列研究采用2004-2013年健康保险和体检资料。纳入根据《国际疾病分类-第十次修订代码》新诊断为癫痫且无情绪障碍病史的患者。癫痫组和对照组的平均随访时间分别为3.57年和4.07年。采用调整人口统计学和健康变量的Cox比例风险模型来估计癫痫诊断后发生情绪障碍的风险。结果共纳入2210例癫痫患者和22100例非癫痫对照。与对照组相比,患者出现情绪障碍的风险增加了3倍(发病率比:3.10[95%可信区间(CI): 2.75-3.49])。诊断后的头两年风险最高(校正风险比:3.42 [95% CI: 2.90-4.03])。诊断后8-10年的风险也显著增加(校正风险比:3.07 [95% CI: 1.14-8.22]),表明存在持续的长期风险。结论癫痫可显著增加心境障碍的发生风险,且在确诊后不久发病风险最高。持续监测和量身定制的干预措施对于管理患者的精神健康至关重要。需要综合护理方法来治疗癫痫和相关的情绪障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Risk of mood disorders after epilepsy diagnosis: A nationwide retrospective cohort study in South Korea.

ObjectiveEpilepsy is a globally prevalent neurological condition associated with mood disorders such as depression and bipolar disorder. This study analyzed the prevalence of and hazard ratios for mood disorders, as well as risk factors, among patients with newly diagnosed epilepsy using a comprehensive South Korean national health database.MethodHealth insurance and health examination data (2004-2013) were utilized in this retrospective cohort study. Patients newly diagnosed with epilepsy based on International Classification of Diseases-10th revision codes and without a mood disorder history were included. Mean follow-up duration was 3.6 years and 4.1 years for the epilepsy and control cohorts, respectively. Cox proportional hazards models adjusted for demographic and health variables were used to estimate the risk of developing mood disorders post-epilepsy diagnosis.ResultsA total of 2210 patients with epilepsy and 22,100 matched controls without epilepsy were included. Those with epilepsy exhibited a 3-fold increased risk of developing mood disorders compared with controls (incidence rate ratio: 3.10 [95% confidence interval (CI): 2.75-3.49]). The risk was highest in the first two years post-diagnosis (adjusted hazard ratio: 3.42 [95% CI: 2.90-4.03]). A notable increase in risk was also observed 8-10 years post-diagnosis (adjusted hazard ratio: 3.07 [(95% CI: 1.14-8.22]), indicating a sustained long-term risk.ConclusionsEpilepsy significantly increases the risk of mood disorders, with the highest risk observed shortly after diagnosis. Continuous monitoring and tailored interventions are essential for managing patients' mental health. Integrated care approaches are needed to treat epilepsy and associated mood disorders.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
3.00
自引率
5.00%
发文量
55
审稿时长
6-12 weeks
期刊介绍: The International Journal of Psychiatry in Medicine (IJPM) bridges the gap between clinical psychiatry research and primary care clinical research. Providing a forum for addressing: The relevance of psychobiological, psychological, social, familial, religious, and cultural factors in the development and treatment of illness; the relationship of biomarkers to psychiatric symptoms and syndromes in primary care...
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信