Takahiro Higuchi, Xinyu Chen, Maximilian Scheifele, Maximilian Fischer, Sebastian Clauss, Konrad Klimek, Rudolf A Werner
{"title":"18F标记心肌灌注PET：新的心脏成像精度。","authors":"Takahiro Higuchi, Xinyu Chen, Maximilian Scheifele, Maximilian Fischer, Sebastian Clauss, Konrad Klimek, Rudolf A Werner","doi":"10.1016/j.tcm.2025.03.008","DOIUrl":null,"url":null,"abstract":"<p><p>The rising global burden of coronary artery disease (CAD) underscores the need for advanced diagnostic tools. While single-photon emission computed tomography (SPECT) has been the cornerstone for myocardial perfusion imaging (MPI), it is increasingly being supplemented by positron emission tomography (PET) due to superior spatial resolution, sensitivity, and the ability to quantify myocardial blood flow. However, current PET tracers, including Rubidium-82, <sup>13</sup>N-Ammonia, and <sup>15</sup>O-Water, face limitations due to their short half-lives and logistical challenges. The advent of <sup>18</sup>F labeled PET tracers, such as Flurpiridaz F18, promises a new era in cardiac imaging by offering a longer half-life (110 minutes), compatibility with exercise stress testing, and high diagnostic accuracy. This review explores the current landscape of MPI, evaluates the clinical performance of novel <sup>18</sup>F tracers, and discusses their transformative potential in expanding access to PET imaging and improving CAD diagnostics.</p>","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":7.3000,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"<sup>18</sup>F labeled myocardial perfusion PET: New precision in cardiac imaging.\",\"authors\":\"Takahiro Higuchi, Xinyu Chen, Maximilian Scheifele, Maximilian Fischer, Sebastian Clauss, Konrad Klimek, Rudolf A Werner\",\"doi\":\"10.1016/j.tcm.2025.03.008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The rising global burden of coronary artery disease (CAD) underscores the need for advanced diagnostic tools. While single-photon emission computed tomography (SPECT) has been the cornerstone for myocardial perfusion imaging (MPI), it is increasingly being supplemented by positron emission tomography (PET) due to superior spatial resolution, sensitivity, and the ability to quantify myocardial blood flow. However, current PET tracers, including Rubidium-82, <sup>13</sup>N-Ammonia, and <sup>15</sup>O-Water, face limitations due to their short half-lives and logistical challenges. The advent of <sup>18</sup>F labeled PET tracers, such as Flurpiridaz F18, promises a new era in cardiac imaging by offering a longer half-life (110 minutes), compatibility with exercise stress testing, and high diagnostic accuracy. This review explores the current landscape of MPI, evaluates the clinical performance of novel <sup>18</sup>F tracers, and discusses their transformative potential in expanding access to PET imaging and improving CAD diagnostics.</p>\",\"PeriodicalId\":51199,\"journal\":{\"name\":\"Trends in Cardiovascular Medicine\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":7.3000,\"publicationDate\":\"2025-04-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Trends in Cardiovascular Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.tcm.2025.03.008\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Cardiovascular Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.tcm.2025.03.008","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
18F labeled myocardial perfusion PET: New precision in cardiac imaging.
The rising global burden of coronary artery disease (CAD) underscores the need for advanced diagnostic tools. While single-photon emission computed tomography (SPECT) has been the cornerstone for myocardial perfusion imaging (MPI), it is increasingly being supplemented by positron emission tomography (PET) due to superior spatial resolution, sensitivity, and the ability to quantify myocardial blood flow. However, current PET tracers, including Rubidium-82, 13N-Ammonia, and 15O-Water, face limitations due to their short half-lives and logistical challenges. The advent of 18F labeled PET tracers, such as Flurpiridaz F18, promises a new era in cardiac imaging by offering a longer half-life (110 minutes), compatibility with exercise stress testing, and high diagnostic accuracy. This review explores the current landscape of MPI, evaluates the clinical performance of novel 18F tracers, and discusses their transformative potential in expanding access to PET imaging and improving CAD diagnostics.
期刊介绍：
Trends in Cardiovascular Medicine delivers comprehensive, state-of-the-art reviews of scientific advancements in cardiovascular medicine, penned and scrutinized by internationally renowned experts. The articles provide authoritative insights into various topics, encompassing basic mechanisms, diagnosis, treatment, and prognosis of heart and blood vessel disorders, catering to clinicians and basic scientists alike. The journal covers a wide spectrum of cardiology, offering profound insights into aspects ranging from arrhythmias to vasculopathies.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
