Gia Han Le, Angela T H Kwan, Ziji Guo, Donovan A Dev, Sabrina Wong, Sebastian Badulescu, Felicia Ceban, Kayla M Teopiz, Danica E Johnson, Hartej Gill, Joshua D Di Vincenzo, Shakila Meshkat, Taeho Greg Rhee, Roger Ho, Lee Phan, Joshua D Rosenblat, Rodrigo B Mansur, Mehala Subramaniapillai, Roger S McIntyre
{"title":"疲劳对covid -19后患者主客观认知功能的影响","authors":"Gia Han Le, Angela T H Kwan, Ziji Guo, Donovan A Dev, Sabrina Wong, Sebastian Badulescu, Felicia Ceban, Kayla M Teopiz, Danica E Johnson, Hartej Gill, Joshua D Di Vincenzo, Shakila Meshkat, Taeho Greg Rhee, Roger Ho, Lee Phan, Joshua D Rosenblat, Rodrigo B Mansur, Mehala Subramaniapillai, Roger S McIntyre","doi":"10.1177/10547738251329412","DOIUrl":null,"url":null,"abstract":"<p><p>Post-COVID-19 condition (PCC) is a serious debilitating condition that develops after the resolution of an acute infection of severe acute respiratory syndrome-associated coronavirus 2. Some commonly reported symptoms include fatigue and cognitive deficits. Multiple lines of evidence have indicated fatigue to be associated with cognitive deficits in the general population. Herein, we perform a secondary analysis of the effects of fatigue on subjective and objective cognition in persons with PCC using a generalized linear model. In this study, fatigue was measured using the Fatigue Severity Scale (FSS) and cognition was measured using the Digit-Symbol Substitution Test (DSST) and the Trails Making Test parts A and B (TMT-A/B). FSS had a statistically significant negative correlation with DSST and TMT-A/B scores. Fatigue serves as a possible target for the development of PCC therapeutics. Fatigue and cognition correlates should be further investigated for underlying neurobiological substrates in persons with PCC.</p>","PeriodicalId":50677,"journal":{"name":"Clinical Nursing Research","volume":"34 3-4","pages":"143-152"},"PeriodicalIF":1.7000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of Fatigue on Subjective and Objective Cognitive Functions in Persons with Post-COVID-19 Condition.\",\"authors\":\"Gia Han Le, Angela T H Kwan, Ziji Guo, Donovan A Dev, Sabrina Wong, Sebastian Badulescu, Felicia Ceban, Kayla M Teopiz, Danica E Johnson, Hartej Gill, Joshua D Di Vincenzo, Shakila Meshkat, Taeho Greg Rhee, Roger Ho, Lee Phan, Joshua D Rosenblat, Rodrigo B Mansur, Mehala Subramaniapillai, Roger S McIntyre\",\"doi\":\"10.1177/10547738251329412\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Post-COVID-19 condition (PCC) is a serious debilitating condition that develops after the resolution of an acute infection of severe acute respiratory syndrome-associated coronavirus 2. Some commonly reported symptoms include fatigue and cognitive deficits. Multiple lines of evidence have indicated fatigue to be associated with cognitive deficits in the general population. Herein, we perform a secondary analysis of the effects of fatigue on subjective and objective cognition in persons with PCC using a generalized linear model. In this study, fatigue was measured using the Fatigue Severity Scale (FSS) and cognition was measured using the Digit-Symbol Substitution Test (DSST) and the Trails Making Test parts A and B (TMT-A/B). FSS had a statistically significant negative correlation with DSST and TMT-A/B scores. Fatigue serves as a possible target for the development of PCC therapeutics. Fatigue and cognition correlates should be further investigated for underlying neurobiological substrates in persons with PCC.</p>\",\"PeriodicalId\":50677,\"journal\":{\"name\":\"Clinical Nursing Research\",\"volume\":\"34 3-4\",\"pages\":\"143-152\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Nursing Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/10547738251329412\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/15 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"NURSING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Nursing Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/10547738251329412","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/15 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"NURSING","Score":null,"Total":0}
Impact of Fatigue on Subjective and Objective Cognitive Functions in Persons with Post-COVID-19 Condition.
Post-COVID-19 condition (PCC) is a serious debilitating condition that develops after the resolution of an acute infection of severe acute respiratory syndrome-associated coronavirus 2. Some commonly reported symptoms include fatigue and cognitive deficits. Multiple lines of evidence have indicated fatigue to be associated with cognitive deficits in the general population. Herein, we perform a secondary analysis of the effects of fatigue on subjective and objective cognition in persons with PCC using a generalized linear model. In this study, fatigue was measured using the Fatigue Severity Scale (FSS) and cognition was measured using the Digit-Symbol Substitution Test (DSST) and the Trails Making Test parts A and B (TMT-A/B). FSS had a statistically significant negative correlation with DSST and TMT-A/B scores. Fatigue serves as a possible target for the development of PCC therapeutics. Fatigue and cognition correlates should be further investigated for underlying neurobiological substrates in persons with PCC.
期刊介绍:
Clinical Nursing Research (CNR) is a peer-reviewed quarterly journal that addresses issues of clinical research that are meaningful to practicing nurses, providing an international forum to encourage discussion among clinical practitioners, enhance clinical practice by pinpointing potential clinical applications of the latest scholarly research, and disseminate research findings of particular interest to practicing nurses. This journal is a member of the Committee on Publication Ethics (COPE).