疲劳对covid -19后患者主客观认知功能的影响

IF 1.7 4区 医学 Q2 NURSING
Clinical Nursing Research Pub Date : 2025-05-01 Epub Date: 2025-04-15 DOI:10.1177/10547738251329412
Gia Han Le, Angela T H Kwan, Ziji Guo, Donovan A Dev, Sabrina Wong, Sebastian Badulescu, Felicia Ceban, Kayla M Teopiz, Danica E Johnson, Hartej Gill, Joshua D Di Vincenzo, Shakila Meshkat, Taeho Greg Rhee, Roger Ho, Lee Phan, Joshua D Rosenblat, Rodrigo B Mansur, Mehala Subramaniapillai, Roger S McIntyre
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引用次数: 0

摘要

covid -19后状态(PCC)是严重急性呼吸综合征相关冠状病毒急性感染消退后出现的严重衰弱状态。一些常见的症状包括疲劳和认知障碍。多项证据表明,在一般人群中,疲劳与认知缺陷有关。在此,我们使用广义线性模型对疲劳对PCC患者主观和客观认知的影响进行了二次分析。本研究采用疲劳严重性量表(FSS)测量疲劳程度,采用数字符号替换测验(DSST)和轨迹制作测试A、B (TMT-A/B)测量认知程度。FSS与DSST、TMT-A/B评分呈显著负相关。疲劳可以作为PCC治疗方法发展的可能目标。疲劳和认知的相关性应该进一步研究PCC患者潜在的神经生物学基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of Fatigue on Subjective and Objective Cognitive Functions in Persons with Post-COVID-19 Condition.

Post-COVID-19 condition (PCC) is a serious debilitating condition that develops after the resolution of an acute infection of severe acute respiratory syndrome-associated coronavirus 2. Some commonly reported symptoms include fatigue and cognitive deficits. Multiple lines of evidence have indicated fatigue to be associated with cognitive deficits in the general population. Herein, we perform a secondary analysis of the effects of fatigue on subjective and objective cognition in persons with PCC using a generalized linear model. In this study, fatigue was measured using the Fatigue Severity Scale (FSS) and cognition was measured using the Digit-Symbol Substitution Test (DSST) and the Trails Making Test parts A and B (TMT-A/B). FSS had a statistically significant negative correlation with DSST and TMT-A/B scores. Fatigue serves as a possible target for the development of PCC therapeutics. Fatigue and cognition correlates should be further investigated for underlying neurobiological substrates in persons with PCC.

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来源期刊
CiteScore
3.40
自引率
5.90%
发文量
107
审稿时长
>12 weeks
期刊介绍: Clinical Nursing Research (CNR) is a peer-reviewed quarterly journal that addresses issues of clinical research that are meaningful to practicing nurses, providing an international forum to encourage discussion among clinical practitioners, enhance clinical practice by pinpointing potential clinical applications of the latest scholarly research, and disseminate research findings of particular interest to practicing nurses. This journal is a member of the Committee on Publication Ethics (COPE).
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