{"title":"[抗细胞因子自身抗体引起的免疫缺陷及相关感染]。","authors":"S Q Liang, B Cao, Z Y He","doi":"10.3760/cma.j.cn112147-20241014-00605","DOIUrl":null,"url":null,"abstract":"<p><p>Anti-cytokine autoantibody (AAb) is produced by plasma cells and interfere with the signaling pathways of their respective cytokines, thereby blocking the biological functions of these target cytokines. This disruption increases the susceptibility of patients to pathogens, leading to recurrent and complex infections. Known anti-cytokine autoantibodies include those against interferon, granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-6, IL-17, and IL-12/23. These antibodies are associated with immune deficiency-related infections. This review summarizes the clinical manifestations and underlying mechanisms of these diseases.</p>","PeriodicalId":61512,"journal":{"name":"中华结核和呼吸杂志","volume":"48 5","pages":"487-492"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Immunodeficiency and related infections caused by anti-cytokine autoantibody].\",\"authors\":\"S Q Liang, B Cao, Z Y He\",\"doi\":\"10.3760/cma.j.cn112147-20241014-00605\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Anti-cytokine autoantibody (AAb) is produced by plasma cells and interfere with the signaling pathways of their respective cytokines, thereby blocking the biological functions of these target cytokines. This disruption increases the susceptibility of patients to pathogens, leading to recurrent and complex infections. Known anti-cytokine autoantibodies include those against interferon, granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-6, IL-17, and IL-12/23. These antibodies are associated with immune deficiency-related infections. This review summarizes the clinical manifestations and underlying mechanisms of these diseases.</p>\",\"PeriodicalId\":61512,\"journal\":{\"name\":\"中华结核和呼吸杂志\",\"volume\":\"48 5\",\"pages\":\"487-492\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-05-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中华结核和呼吸杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/cma.j.cn112147-20241014-00605\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华结核和呼吸杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/cma.j.cn112147-20241014-00605","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[Immunodeficiency and related infections caused by anti-cytokine autoantibody].
Anti-cytokine autoantibody (AAb) is produced by plasma cells and interfere with the signaling pathways of their respective cytokines, thereby blocking the biological functions of these target cytokines. This disruption increases the susceptibility of patients to pathogens, leading to recurrent and complex infections. Known anti-cytokine autoantibodies include those against interferon, granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-6, IL-17, and IL-12/23. These antibodies are associated with immune deficiency-related infections. This review summarizes the clinical manifestations and underlying mechanisms of these diseases.
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