Derek M Dean, Lillian E Codd, Ruben Constanza, Xavier M Segel
{"title":"purpleoid 1是一种典型的果蝇眼睛颜色突变，是t- snare编码基因SNAP29的等位基因。","authors":"Derek M Dean, Lillian E Codd, Ruben Constanza, Xavier M Segel","doi":"10.17912/micropub.biology.001563","DOIUrl":null,"url":null,"abstract":"<p><p>The <i>Drosophila</i> mutant eye color trait <i>purpleoid</i> ( <i>pd</i> ) was first observed by Calvin Bridges over a century ago. Although <i>pd</i> mutant strains have been maintained ever since, the <i>pd</i> locus has not been identified. Using complementation tests, genetic rescue, and DNA sequencing, we show that <i>pd <sup>1</sup></i> is a missense mutation in <i>SNAP29</i> ; this gene encodes a key component of the SNARE complex, which facilitates vesicle docking and fusion at cellular membranes. After describing how <i>pd <sup>1</sup></i> was mapped, we discuss ways that the mutation could be used in future studies of eye pigmentation, SNARE complex assembly, and vesicle trafficking.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12015646/pdf/","citationCount":"0","resultStr":"{\"title\":\"<i>purpleoid <sup>1</sup></i> , a classic <i>Drosophila</i> eye color mutation, is an allele of the t-SNARE-encoding gene <i>SNAP29</i>.\",\"authors\":\"Derek M Dean, Lillian E Codd, Ruben Constanza, Xavier M Segel\",\"doi\":\"10.17912/micropub.biology.001563\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The <i>Drosophila</i> mutant eye color trait <i>purpleoid</i> ( <i>pd</i> ) was first observed by Calvin Bridges over a century ago. Although <i>pd</i> mutant strains have been maintained ever since, the <i>pd</i> locus has not been identified. Using complementation tests, genetic rescue, and DNA sequencing, we show that <i>pd <sup>1</sup></i> is a missense mutation in <i>SNAP29</i> ; this gene encodes a key component of the SNARE complex, which facilitates vesicle docking and fusion at cellular membranes. After describing how <i>pd <sup>1</sup></i> was mapped, we discuss ways that the mutation could be used in future studies of eye pigmentation, SNARE complex assembly, and vesicle trafficking.</p>\",\"PeriodicalId\":74192,\"journal\":{\"name\":\"microPublication biology\",\"volume\":\"2025 \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-04-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12015646/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"microPublication biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17912/micropub.biology.001563\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"microPublication biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17912/micropub.biology.001563","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
purpleoid 1 , a classic Drosophila eye color mutation, is an allele of the t-SNARE-encoding gene SNAP29.
The Drosophila mutant eye color trait purpleoid ( pd ) was first observed by Calvin Bridges over a century ago. Although pd mutant strains have been maintained ever since, the pd locus has not been identified. Using complementation tests, genetic rescue, and DNA sequencing, we show that pd 1 is a missense mutation in SNAP29 ; this gene encodes a key component of the SNARE complex, which facilitates vesicle docking and fusion at cellular membranes. After describing how pd 1 was mapped, we discuss ways that the mutation could be used in future studies of eye pigmentation, SNARE complex assembly, and vesicle trafficking.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
