{"title":"先进的血液透析系统：评估老年慢性肾病患者的炎症生物标志物、肾脏分析和代谢稳定性。","authors":"Hong Zhang, Meiling Liu, Jun Wu","doi":"10.1177/09287329251332413","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease (CKD) in the elderly necessitates innovative therapeutic technologies to address systemic complications. Advanced hemodialysis systems, integrating real-time biochemical monitoring and optimized filtration, offer potential enhancements in clinical outcomes, yet their impact on inflammatory pathways and metabolic equilibrium remains underexplored.</p><p><strong>Objective: </strong>This study evaluated the efficacy of a next-generation hemodialysis system in modulating inflammatory biomarkers, renal function parameters, and calcium-phosphorus homeostasis among elderly CKD patients.</p><p><strong>Methods: </strong>Eighty-four elderly CKD patients were randomized into a control group (standard therapy) and an intervention group (standard therapy + advanced hemodialysis). The intervention utilized a fully automated dialysis machine with bicarbonate dialysate, precision-calibrated blood flow (180-200 mL/min), and real-time metabolic tracking. Serum levels of TNF-α, IL-6, IL-1, hs-CRP, BUN, Scr, β2-MG, calcium, phosphorus, and Ca × P were analyzed pre- and post-intervention using ELISA and biochemical assays.</p><p><strong>Results: </strong>The intervention group demonstrated a higher total efficacy rate (85.71% vs. 64.29%, P < 0.05). Post-treatment, significant reductions in inflammatory markers (TNF-α: 1.35 ± 0.24 vs. 4.06 ± 0.42 ng/mL; IL-6: 13.05 ± 1.52 vs. 17.62 ± 2.24 ng/L), renal toxins (BUN: 7.82 ± 1.75 vs. 10.12 ± 2.02 mmol/L; Scr: 401.32 ± 15.76 vs. 489.95 ± 16.14 μmol/L), and phosphorus (1.62 ± 0.34 vs. 2.16 ± 0.46 mmol/L) were observed (P < 0.05). Calcium levels improved (3.19 ± 0.56 vs. 2.26 ± 0.53 mmol/L), alongside stabilized Ca × P products (52.92 ± 5.05 vs. 60.34 ± 7.06 mg<sup>2</sup>/dL).</p><p><strong>Conclusion: </strong>Advanced hemodialysis systems significantly enhance therapeutic outcomes in elderly CKD patients by attenuating inflammation, restoring renal function, and optimizing calcium-phosphorus metabolism. These findings underscore the clinical value of integrating technology-driven dialysis protocols for precision care.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"2177-2183"},"PeriodicalIF":1.8000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Advanced hemodialysis systems: Assessing inflammatory biomarkers, renal analytics, and metabolic stability in elderly patients with chronic kidney disease.\",\"authors\":\"Hong Zhang, Meiling Liu, Jun Wu\",\"doi\":\"10.1177/09287329251332413\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Chronic kidney disease (CKD) in the elderly necessitates innovative therapeutic technologies to address systemic complications. Advanced hemodialysis systems, integrating real-time biochemical monitoring and optimized filtration, offer potential enhancements in clinical outcomes, yet their impact on inflammatory pathways and metabolic equilibrium remains underexplored.</p><p><strong>Objective: </strong>This study evaluated the efficacy of a next-generation hemodialysis system in modulating inflammatory biomarkers, renal function parameters, and calcium-phosphorus homeostasis among elderly CKD patients.</p><p><strong>Methods: </strong>Eighty-four elderly CKD patients were randomized into a control group (standard therapy) and an intervention group (standard therapy + advanced hemodialysis). The intervention utilized a fully automated dialysis machine with bicarbonate dialysate, precision-calibrated blood flow (180-200 mL/min), and real-time metabolic tracking. Serum levels of TNF-α, IL-6, IL-1, hs-CRP, BUN, Scr, β2-MG, calcium, phosphorus, and Ca × P were analyzed pre- and post-intervention using ELISA and biochemical assays.</p><p><strong>Results: </strong>The intervention group demonstrated a higher total efficacy rate (85.71% vs. 64.29%, P < 0.05). Post-treatment, significant reductions in inflammatory markers (TNF-α: 1.35 ± 0.24 vs. 4.06 ± 0.42 ng/mL; IL-6: 13.05 ± 1.52 vs. 17.62 ± 2.24 ng/L), renal toxins (BUN: 7.82 ± 1.75 vs. 10.12 ± 2.02 mmol/L; Scr: 401.32 ± 15.76 vs. 489.95 ± 16.14 μmol/L), and phosphorus (1.62 ± 0.34 vs. 2.16 ± 0.46 mmol/L) were observed (P < 0.05). Calcium levels improved (3.19 ± 0.56 vs. 2.26 ± 0.53 mmol/L), alongside stabilized Ca × P products (52.92 ± 5.05 vs. 60.34 ± 7.06 mg<sup>2</sup>/dL).</p><p><strong>Conclusion: </strong>Advanced hemodialysis systems significantly enhance therapeutic outcomes in elderly CKD patients by attenuating inflammation, restoring renal function, and optimizing calcium-phosphorus metabolism. 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引用次数: 0
摘要
背景：老年人慢性肾脏疾病（CKD）需要创新的治疗技术来解决全身并发症。先进的血液透析系统，集成了实时生化监测和优化过滤，提供了潜在的临床结果增强，但其对炎症途径和代谢平衡的影响仍未得到充分探讨。目的：本研究评估新一代血液透析系统对老年CKD患者炎症生物标志物、肾功能参数和钙磷稳态的调节作用。方法84例老年CKD患者随机分为对照组（标准治疗）和干预组（标准治疗+晚期血液透析）。干预使用全自动透析机，使用碳酸氢盐透析液，精确校准血流量（180-200 mL/min），并实时代谢跟踪。采用ELISA法和生化法分析干预前后血清TNF-α、IL-6、IL-1、hs-CRP、BUN、Scr、β2-MG、钙、磷、Ca × P水平。结果干预组总有效率高于对照组（85.71% vs. 64.29%, P 2/dL）。结论先进的血液透析系统通过减轻炎症、恢复肾功能和优化钙磷代谢，显著提高老年CKD患者的治疗效果。这些发现强调了将技术驱动的透析方案整合到精确护理中的临床价值。
Advanced hemodialysis systems: Assessing inflammatory biomarkers, renal analytics, and metabolic stability in elderly patients with chronic kidney disease.
Background: Chronic kidney disease (CKD) in the elderly necessitates innovative therapeutic technologies to address systemic complications. Advanced hemodialysis systems, integrating real-time biochemical monitoring and optimized filtration, offer potential enhancements in clinical outcomes, yet their impact on inflammatory pathways and metabolic equilibrium remains underexplored.
Objective: This study evaluated the efficacy of a next-generation hemodialysis system in modulating inflammatory biomarkers, renal function parameters, and calcium-phosphorus homeostasis among elderly CKD patients.
Methods: Eighty-four elderly CKD patients were randomized into a control group (standard therapy) and an intervention group (standard therapy + advanced hemodialysis). The intervention utilized a fully automated dialysis machine with bicarbonate dialysate, precision-calibrated blood flow (180-200 mL/min), and real-time metabolic tracking. Serum levels of TNF-α, IL-6, IL-1, hs-CRP, BUN, Scr, β2-MG, calcium, phosphorus, and Ca × P were analyzed pre- and post-intervention using ELISA and biochemical assays.
Results: The intervention group demonstrated a higher total efficacy rate (85.71% vs. 64.29%, P < 0.05). Post-treatment, significant reductions in inflammatory markers (TNF-α: 1.35 ± 0.24 vs. 4.06 ± 0.42 ng/mL; IL-6: 13.05 ± 1.52 vs. 17.62 ± 2.24 ng/L), renal toxins (BUN: 7.82 ± 1.75 vs. 10.12 ± 2.02 mmol/L; Scr: 401.32 ± 15.76 vs. 489.95 ± 16.14 μmol/L), and phosphorus (1.62 ± 0.34 vs. 2.16 ± 0.46 mmol/L) were observed (P < 0.05). Calcium levels improved (3.19 ± 0.56 vs. 2.26 ± 0.53 mmol/L), alongside stabilized Ca × P products (52.92 ± 5.05 vs. 60.34 ± 7.06 mg2/dL).
Conclusion: Advanced hemodialysis systems significantly enhance therapeutic outcomes in elderly CKD patients by attenuating inflammation, restoring renal function, and optimizing calcium-phosphorus metabolism. These findings underscore the clinical value of integrating technology-driven dialysis protocols for precision care.
期刊介绍：
Technology and Health Care is intended to serve as a forum for the presentation of original articles and technical notes, observing rigorous scientific standards. Furthermore, upon invitation, reviews, tutorials, discussion papers and minisymposia are featured. The main focus of THC is related to the overlapping areas of engineering and medicine. The following types of contributions are considered:
1.Original articles: New concepts, procedures and devices associated with the use of technology in medical research and clinical practice are presented to a readership with a widespread background in engineering and/or medicine. In particular, the clinical benefit deriving from the application of engineering methods and devices in clinical medicine should be demonstrated. Typically, full length original contributions have a length of 4000 words, thereby taking duly into account figures and tables.
2.Technical Notes and Short Communications: Technical Notes relate to novel technical developments with relevance for clinical medicine. In Short Communications, clinical applications are shortly described. 3.Both Technical Notes and Short Communications typically have a length of 1500 words.
Reviews and Tutorials (upon invitation only): Tutorial and educational articles for persons with a primarily medical background on principles of engineering with particular significance for biomedical applications and vice versa are presented. The Editorial Board is responsible for the selection of topics.
4.Minisymposia (upon invitation only): Under the leadership of a Special Editor, controversial or important issues relating to health care are highlighted and discussed by various authors.
5.Letters to the Editors: Discussions or short statements (not indexed).
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