胰岛素敏感性指数独立预测长期运动青少年血清IGF-1下降。

IF 5.4 2区医学 Q1 Medicine

Journal of Endocrinological Investigation Pub Date : 2025-05-05 DOI:10.1007/s40618-025-02562-z

Xiaoyuan Guo, Jiaqi Qiang, Zhibo Zhou, Yuxin Sun, Yutong Wang, Yuelun Zhang, Hongbo Yang, Huijuan Zhu, Mei Zhang, Bo Ban, Shi Chen, Hui Pan

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引用次数: 0

摘要

背景：本研究旨在探讨长期运动训练的青少年胰岛素敏感性和胰岛素样生长因子-1 （IGF-1）之间的关系，并评估其对生长的影响。方法：采用前瞻性队列研究，对一所普通高中（非运动组，年龄13.3±0.5岁，n = 149）和一所运动训练学校（运动组，年龄13.5±1.3岁，n = 100）进行为期1年的随访。采用定量胰岛素敏感性检查指数（QUICKI）评估生长指标、胰岛素敏感性和IGF-1水平。结果：运动组的参与者表现出较高的QUICKI和较低的IGF-1水平。在运动组中，IGF-1在基线和随访时与QUICKI横断面独立相关。纵向分析显示，运动组基线QUICKI与随访时IGF-1水平独立相关（β = -532.926, P = 0.032）。非运动组没有发现这种关联。此外，运动组未观察到生长指标的损害。结论：我们的研究结果表明，QUICKI是长期运动的青少年中IGF-1水平的独立预测因子。

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Insulin sensitivity index independently predicts serum IGF-1 decreases in adolescents with long-term exercise.

Background: The study aims to investigate associations between insulin sensitivity and insulin-like growth factor-1 (IGF-1) in adolescents engaged in long-term exercise training, and to assess the impact on growth.

Methods: We conducted a prospective cohort study and followed for 1 year from a general high school (non-exercise group, age 13.3 ± 0.5 years, n = 149) and an exercise training school (exercise group, age 13.5 ± 1.3 years, n = 100). Growth indices, insulin sensitivity assessed using the Quantitative Insulin Sensitivity Check Index (QUICKI), and IGF-1 levels were obtained.

Results: Participants in the exercise group exhibited higher QUICKI and lower IGF-1 levels. In the exercise group, IGF-1 was independently associated with QUICKI cross-sectionally at baseline and follow-up. Longitudinal analysis revealed that QUICKI at baseline was independently associated with IGF-1 levels at follow-up in the exercise group (β = -532.926, P = 0.032). Such associations were not found in non-exercise group. Additionally, no impairments in growth indices were observed in the exercise group.

Conclusions: Our findings suggest that QUICKI is an independent predictor of IGF-1 levels in adolescents with a long-term exercise regimen.

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来源期刊

Journal of Endocrinological Investigation ENDOCRINOLOGY & METABOLISM-

CiteScore

8.10

自引率

7.40%

发文量

242

期刊介绍： The Journal of Endocrinological Investigation is a well-established, e-only endocrine journal founded 36 years ago in 1978. It is the official journal of the Italian Society of Endocrinology (SIE), established in 1964. Other Italian societies in the endocrinology and metabolism field are affiliated to the journal: Italian Society of Andrology and Sexual Medicine, Italian Society of Obesity, Italian Society of Pediatric Endocrinology and Diabetology, Clinical Endocrinologists’ Association, Thyroid Association, Endocrine Surgical Units Association, Italian Society of Pharmacology.