Eleonora Salles-Silva MD , Paula Lemos de Castro MD , Luiza Carvalho Ambrozino MD , Antonio Luis-Eiras de Araújo MD, PhD , Daniel Lahan-Martins MD, PhD , Maria Fernanda Arruda Almeida MD, PhD , Fabiano Rubião Lucchesi MD, PhD , Eduardo Oliveira Pacheco MD , Ulysses S. Torres MD, PhD , Giuseppe D’Ippolito MD, PhD , Daniella Braz Parente MD, PhD
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This review highlights the main radiologic characteristics of selected rare malignant liver tumors—including fibrolamellar hepatocellular carcinoma, hepatic lymphoma, hepatocellular carcinoma in non-cirrhotic liver, mucinous cystic neoplasm, intraductal papillary neoplasm of the bile duct, epithelioid hemangioendothelioma, angiosarcoma, malignant hepatic adenoma, neuroendocrine tumor, hepatocholangiocarcinoma, hepatoblastoma, undifferentiated embryonal sarcoma, and infantile hepatic hemangioendothelioma—focusing on their presentation in computed tomography and magnetic resonance imaging. Recognizing specific imaging findings, such as arterial hyperenhancement, biliary communication, target and lollipop signs, and tumor morphology, can help narrow differential diagnoses and guide appropriate clinical management. Despite advancements in imaging, histopathologic confirmation is often required due to nonspecific features. Improved radiologic awareness of these rare entities is essential to facilitate early diagnosis and individualized treatment planning.</div></div>","PeriodicalId":49541,"journal":{"name":"Seminars in Ultrasound Ct and Mri","volume":"46 3","pages":"Pages 161-176"},"PeriodicalIF":1.5000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Rare Malignant Liver Tumors: Current Insights and Imaging Challenges\",\"authors\":\"Eleonora Salles-Silva MD , Paula Lemos de Castro MD , Luiza Carvalho Ambrozino MD , Antonio Luis-Eiras de Araújo MD, PhD , Daniel Lahan-Martins MD, PhD , Maria Fernanda Arruda Almeida MD, PhD , Fabiano Rubião Lucchesi MD, PhD , Eduardo Oliveira Pacheco MD , Ulysses S. 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Recognizing specific imaging findings, such as arterial hyperenhancement, biliary communication, target and lollipop signs, and tumor morphology, can help narrow differential diagnoses and guide appropriate clinical management. Despite advancements in imaging, histopathologic confirmation is often required due to nonspecific features. 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Rare Malignant Liver Tumors: Current Insights and Imaging Challenges
Rare malignant liver tumors (RMLTs) comprise a diverse group of neoplasms with distinct imaging features and significant diagnostic challenges due to their low prevalence and overlap with more common hepatic lesions. This review highlights the main radiologic characteristics of selected rare malignant liver tumors—including fibrolamellar hepatocellular carcinoma, hepatic lymphoma, hepatocellular carcinoma in non-cirrhotic liver, mucinous cystic neoplasm, intraductal papillary neoplasm of the bile duct, epithelioid hemangioendothelioma, angiosarcoma, malignant hepatic adenoma, neuroendocrine tumor, hepatocholangiocarcinoma, hepatoblastoma, undifferentiated embryonal sarcoma, and infantile hepatic hemangioendothelioma—focusing on their presentation in computed tomography and magnetic resonance imaging. Recognizing specific imaging findings, such as arterial hyperenhancement, biliary communication, target and lollipop signs, and tumor morphology, can help narrow differential diagnoses and guide appropriate clinical management. Despite advancements in imaging, histopathologic confirmation is often required due to nonspecific features. Improved radiologic awareness of these rare entities is essential to facilitate early diagnosis and individualized treatment planning.
期刊介绍:
Seminars in Ultrasound, CT and MRI is directed to all physicians involved in the performance and interpretation of ultrasound, computed tomography, and magnetic resonance imaging procedures. It is a timely source for the publication of new concepts and research findings directly applicable to day-to-day clinical practice. The articles describe the performance of various procedures together with the authors'' approach to problems of interpretation.